ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Eating more vegetable protein may protect against early menopause

Is Activated Charcoal Beneficial?

 
Print Page
Email Article

Anti-polymer antibody in Italian Fibromyalgic patients

  [ Not Yet Rated ]   [ Discuss This Article ]
By Bazzichi L, et al. • www.ProHealth.com • September 11, 2007


The objectives of our study were to evaluate the presence of antipolymer antibody (APA) seropositivity in 285 Italian patients affected by primary Fibromyalgia (FM) and to verify if APA levels correlate with the disease severity and cytokine levels. [Note: Some research has suggested that levels of APA (antibody to silicone polymers and their breakdown products) in Fibromyalgia patients’ blood serum may be a marker for FM, and that APA levels might be associated with FM symptom severity.]

APA levels were determined on serum samples by an indirect ELISA kit that detect IgG APA. Cytokines (IL-1, IL-6, IL-8, IL-10 and TNF-alpha) were measured by ELISA in plasma. The impact of Fibromyalgia on the quality of life was estimated using the "Fibromyalgia Impact Questionnaire" (FIQ), while pain severity was evaluated using a Visual Analogic Scale (VAS). Patients were also characterized by the presence of tiredness, stiffness, non restorative sleep, anxiety, depression, tension headache, irritable bowel syndrome, temporomandibular dysfunction, Raynaud phenomena.

Using a cut-off value of 30 U, APA positive values were detected in 60 FM patients (21.05%) and in 15 healthy controls (15.00%) without significant differences among their levels or percentage of seropositivity.

FM patients with moderate and severe symptoms had slightly higher APA levels with respect to patients with mild symptoms.

APA seropositive patients exhibited significant correlations between APA levels and FIQ (P=0.042), tiredness (P=0.003) and IL-1 levels (P=0.0072).

In conclusion, APA cannot be considered a marker of disease in Italian FM patients. However, its presence might permit the identification of a subset of FM patients with more severe symptoms and who may respond differently to different therapeutic strategies.

Source: Arthritis Research & Therapy. 2007 Sep 6;9(5):R86 [E-publication ahead of print] PMID: 17822528, by Bazzichi L, Giacomelli C, De Feo F, Giuliano T, Rossi A, Doveri M, Tani C, Wilson RB, Bombardieri S.





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map