Peripheral blood specimens and clinical data were obtained over a 12-month period from subjects in the Dubbo Infection Outcomes Study to examine cytokine production in postinfective fatigue syndrome. [Cytokines are defined as "a group of proteins instrumental in the orchestration of the host immune responses."
Ex vivo production of 8 cytokines was examined in 22 case patients and in 42 control subjects who recovered promptly. No significant differences were found.
Ongoing production of the cytokines examined does not play a role in postinfective fatigue syndrome.
Source: Clinical Infectious Diseases.2007 Sep 15;45(6):732-35. PMID: 17712757, by Vollmer-Conna U, Cameron B, HadziPavlovic D, Singletary K, Davenport T, Vernon S, Reeves RC, Hickie I, Wakefield D, Lloyd AR. Dubbo Infective Outcomes Study Group. School of Psychiatry and Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales; Brain & Mind Research Institute, Sydney University, Sydney, Australia; Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.[E-mail:
See also a press release issued by the University of New South Wales on September 14, 2007 - "Attention turns to brain as driver of Chronic Fatigue symptoms."