The present therapeutic approach is aimed at controlling central sensitization that is supposed to be the core of Fibromyalgia's physiopathological mechanisms.
The tricyclic antidepressants have some effects on sleep and the improvement of physical activities. Encouraging results have been observed with the serotonin and noradrenaline reuptake inhibitors such as venlafaxine, milnacipran or duloxetine.
New Dopamine D3 receptor agonists as well as the new anticonvulsants such as gabapentine and pregabalin are equally promising.
However the prescription of any medication should take place within a multidisciplinary approach.
Source: Revue Medicale Suisse. 2007 Jun 20;3(116):1575-8. PMID: 17727168, by Perot S. Service de médecine interne et consultation de la douleur, Hôtel Dieu, Paris, France. [E-mail: firstname.lastname@example.org ]