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Growth hormone as concomitant treatment in severe Fibromyalgia associated with low IGF-1 serum levels. A pilot study - Source: BMC Musculoskeletal Disorders, Nov 30, 2007

  [ 108 votes ]   [ 1 Comment ]
By Guillem Cuatrecasas, MD, et al. • • December 8, 2007

[Note: The full text of this article is available free of charge at ]

Background: There is evidence of functional growth hormone (GH) deficiency, expressed by means of low insulin-like growth factor 1 (IGF-1) serum levels, in a subset of fibromyalgia patients. The efficacy of GH versus placebo has been previously suggested in this population. We investigated the efficacy and safety of low dose GH as an adjunct to standard therapy in the treatment of severe, prolonged and well-treated fibromyalgia patients with low IGF-1 levels.

Methods: Twenty-four patients were enrolled in a randomized, open-label, best available care-controlled study. Patients were randomly assigned to receive either 0.0125 mg/kg/d of GH subcutaneously (titrated depending on IGF-1) added to standard therapy or standard therapy alone during one year. The number of tender points, the Fibromyalgia Impact Questionnaire (FIQ) and the EuroQol 5D (EQ-5D), including a Quality of Life visual analogic scale (EQ-VAS) were assessed at different time-points.


  • At the end of the study, the GH group showed a 60% reduction in the mean number of tender points (pairs) compared to the control group (p<0.05; 3.25+/-0.8 vs. 8.25+/-0.9).
  • Similar improvements were observed in FIQ score (p<0.05) and EQ-VAS scale (p<0.001).
  • There was a prompt response to GH administration, with most patients showing improvement within the first months in most of the outcomes.
  • The concomitant administration of GH and standard therapy was well tolerated, and no patients discontinued the study due to adverse events.
  • Conclusions: The present findings indicate the advantage of adding a daily GH dose to the standard therapy in a subset of severe fibromyalgia patients with low IGF-1 serum levels.

    Trial Registration: NCT00497562 (

    Source: BMC Musculoskeletal Disorders. 2007 Nov 30;8(1):119 [E-pub ahead of print] PMID: 18053120, by Cuatrecasas G, Riudavets C, Guell MA, Nadal A. Servicio de Endocrinología, Centro Médico Teknon, Barcelona, Spain. [E-mail: Guillem Cuatrecasas, MD,]

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    Article Comments Post a Comment

    Growth Hormone Study
    Posted by: brighteyestish
    Dec 19, 2007
    I was in a 6 month study with a oral growth hormone and It did very well. It took 3-4 months before I started to stop hurting. At the end of the study My tender points not longer hurt...AT ALL. Now that I am off of it I feel sluggish and drained. I hope they put it on the market.
    Reply Reply
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