ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tea drinkers have lower glaucoma risk

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

Basic Aromatherapy to Help Balance and Calm

The Long-Term Benefits of Drinking Oolong Tea

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Wonderful White Tea: A Drink Fit for an Emperor

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

Print Page
Email Article

Fibromyalgia: A Disorder of the Brain? – Source: Neuroscientist, Feb 12, 2008

  [ 135 votes ]   [ 5 Comments ]
By Catherine Bushnell, et al. • • February 15, 2008

This article presents evidence that Fibromyalgia patients have alterations in CNS [central nervous system] anatomy, physiology, and chemistry that potentially contribute to the symptoms experienced by these patients.

n There is substantial psychophysical evidence that Fibromyalgia patients perceive pain and other noxious stimuli differently than healthy individuals and that normal pain modulatory systems, such as diffuse noxious inhibitory control mechanisms, are compromised in Fibromyalgia.

n Furthermore, functional brain imaging studies revealing enhanced pain-related activations corroborate the patients' reports of increased pain.

n Neurotransmitter studies show that Fibromyalgia patients have abnormalities in dopaminergic, opioidergic, and serotoninergic systems.

n Finally, studies of brain anatomy show structural differences between the brains of Fibromyalgia patients and healthy individuals. The cerebral alterations offer a compelling explanation for the multiple symptoms of Fibromyalgia, including widespread pain and affective disturbances.

The frequent comorbidity of Fibromyalgia with stress-related disorders, such as chronic fatigue, posttraumatic stress disorder, irritable bowel syndrome, and depression, as well as the similarity of many CNS abnormalities, suggests at least a partial common substrate for these disorders.

Despite the numerous cerebral alterations, Fibromyalgia might not be a primary disorder of the brain but may be a consequence of early life stress or prolonged or severe stress, affecting brain modulatory circuitry of pain and emotions in genetically susceptible individuals.

Source: Neuroscientist. 2008 Feb 12 [Epub ahead of print] PMID: 18270311, by Schweinhardt P, Sauro KM, Bushnell MC. Center for Research on Pain, McGill University, Montreal, Quebec, Canada. [E-mail:]

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg

Article Comments Post a Comment

Fibromyalgia: A Disorder of the Brain?
Posted by: linda_angel
Feb 18, 2008
..."There is substantial psychophysical evidence that Fibromyalgia patients perceive pain and other noxious stimuli differently than healthy individuals and that normal pain modulatory systems, such as diffuse noxious inhibitory control mechanisms, are compromised in Fibromyalgia..." Is this to say that those who suffer with Fibromyalgia have a lower pain tolerance? In my case I seem to have a HIGHER level of tolerance. For example: I have had several infertility surgeries and a full abdominal hysterectomy and was advised that my recovery period was to be six to eight weeks. I felt as if I was always ready to go back to my "normal" work and every day activities in 3-4 weeks if not for the fatigue. Also, I have had several injuries, including broken several bones and most people are astonished that my recovery period from these have always been so short. This includes a fractured vertebra which I thought was only a "sore back" from a horse back riding fall. I do contend however that I feel the flu like aches and fatigue that most speak of when referring to their Fibromyalgia symptoms and I have frequent and very painful "shooting pains" that seem to have gotten worse as I have aged.
Reply Reply

Fibromyalgia: A Disorder of the Brain?
Posted by: pearls
Mar 5, 2008
As a person with fibromyalgia, it is always heartening to see an article that validates the problem as real. However, it would have been much more valuable had the author listed sources for her points. Further, could it be that fibromyalgia patients have had a neurological event with multiple causes? Could it be that an FMS person's brain is in some way susceptible to such an event, and that it was precipitated by such things as prolonged stress, an accident, an infection, etc. or even a combination of those things? As for a lower threshold, this seems true in many, though perhaps not all, respects. We seem to sense things going on in our bodies as pain, burning, numbness, cold, and so forth which might not be perceptible otherwise. They fall below the pain threshold for most people and are not noticed at all. But for people with fibromyalgia, these perceptions can be debilitating. We also seem to have more muscle spasms, which can cause severe pain. But ordinary pain caused by accidents like running into things, or getting cut doesn't seem any worse than before, at least to me. Pearl S.
Reply Reply

FM can be a descriptive term for Lyme disease
Posted by: munch1958
Mar 6, 2008
I'm not saying "ALL" cases of "FM" are Lyme but some are! The majority of LD patients WERE diagnosed with CFS or FM before getting Lyme diagnoses. For 27 years, I thought it was CFS and FM. Check out the journal articles on the left side toolbar.
Reply Reply

relationship of "emotions" in FMS
Posted by: robingers
Mar 7, 2008
I find this article to be contradictory. In the beginning, the author lists all the diagnostic tests that show that people with FMS have "physical" abnormalities. Then, she proceeds to fall back to the explanation that "stress" or an emotional trauma could be what caused the disorder. I believe this type of explanation is hurting the validation of FMS, because it suggests that the afflicted person was weak and somehow responsible for bringing on the disease. It is so absurd to me that we never blame stress for causing diseases like cancer, heart disease, MS, Parkinson's, etc. Instead we use an arsenal of medications and surgeries and treat the person from a "physical" perspective. Haven't we learned anything from medical history? Whenever a new disorder appears, until we understand the anatomy of it, we always assume there is a psychological origin. We did this with diabetes, Rheumatoid Arthritis, hypothyroidism, etc... Of course stress and emotions contribute to FMS, just like they do with all diseases. But they are not the main cause. Like most diseases, Fibromyalgia is probably a combination of genetics, poor immune system (via unhealthy diets, bacterial/viral infections), chronic toxic chemical exposure (via food, air, water), and stress. And until we stop searching for a psychological connection, Fibromyalgia will not get the medical (including alternative modalities) and physical treatment it requires. Frustrated, Yet Hopeful, Robin
Reply Reply

Brain overload
Posted by: Svette_Palme
Apr 18, 2008
Yup, I like it!! Brain overload, from the same input as other people have. Thats what our problem is, and it does NOT mean we are "not dealing with it well" - it means we have "too much sensory input to deal with". YA!! This is going to be understood someday... [please see my comment on the "Psychophysical Study of Auditory and Pressure Sensitivity" article too!]
Reply Reply

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Live Without Anxiety or Stress Live Without Anxiety or Stress
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map