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Now Recruiting - Trial of TMS (Transcranial Magnetic Stimulation) for Treating Chronic Widespread Pain and/or Fibromyalgia

  [ 42 votes ]   [ 1 Comment ] • April 28, 2008

Researchers at the University of Washington in Seattle are recruiting women with chronic widespread pain – considered “a hallmark feature of Fibromyalgia.” The trial involves a painless interventional treatment using repetitive Transcranial Magnetic Stimulation (rTMS) in 15 sessions over 15 days, with follow-up visits at 1, 4, and 12 weeks.

This trial ( identifier NCT00524420) is sponsored by the National Institute of Arthritis and Musculoskeletal & Skin Diseases (NIAMS) and will measure pain intensity as a primary outcome - as well as a number of secondary outcomes such as depression, fatigue, sleep, and exercise.

According to the trial description:

Chronic widespread pain is characterized by musculoskeletal pain that lasts for at least 3 months, pain above and below the waist, pain on both the right and left sides, and pain in the head, neck, spine, or back. In addition to fatigue, chronic widespread pain is a hallmark feature of fibromyalgia.

Significant physical and emotional effects usually accompany chronic widespread pain and fibromyalgia, making the development of effective treatments a priority.

rTMS involves a neurophysiologic technique that directs a current into the brain by using a magnetic field to pass the scalp and skull safely and painlessly. Stimuli are applied to the same brain area several times per second during several consecutive seconds. rTMS has been found to be effective for treating certain types of chronic pain. The purpose of this study is to determine the effectiveness of rTMS treatment in reducing bodily pain associated with chronic widespread pain and/or fibromyalgia in women.

Participants in this study will undergo a diagnostic interview, physical and neurological exam, electrocardiogram, magnetic resonance imaging, and blood and urine collection for screening purposes.

Eligible participants will then be randomly assigned to receive either rTMS treatment or sham rTMS treatment. One-hour daily treatment sessions will occur over 15 days.

After every five treatment sessions, participants will be interviewed about their pain and depression symptoms, and they will fill out questionnaires about pain, depression, fatigue, sleep, and exercise. Participants will also undergo pain threshold and tolerance testing of their right thumb. On a daily basis, participants will rate their level of pain using a 0 to 20 scale.

Follow-up evaluations will occur 1, 4, and 12 weeks after treatment and will include a repeat interview and testing.

After the follow-up evaluations, any participants who did not respond to the sham treatment will be offered a series of 15 real rTMS treatment sessions.

For more information about the trial and about rTMS, click here.

Contacts, if you might be interested in participating:

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Article Comments Post a Comment

April 28th 2008 Article
Posted by: ccg07
Oct 8, 2009
Oct.8 09 I wish i could participate in your study, for i would very much be interested in anything more i can learn, and how i would and could be a very good candidate for your study about this mysterious slowly life destroying illness, FMS, CFS and all that goes with in. Oh, How i hate it. I have had this for over 30 yrs and always in the chronic stages, have had almost 0000 good days, more on the flat on my back, and lately it's starting to affect my stomach and colon = elimination is a serious problem ,unable to without alot of laxative, = vomitting as well, My insides are not working as they should, due mainly for the high dose of medication that i take, I'm at a stage now where i am considering Detoxing slowly, for when i needed to have a Colonoscopy and a Gastroscopy. The medical staff could not put me out, nor could they give me anything for my regular pain. So at the same time as the procedures were being done, i was going into withdrawl, and that is what scared me. God forbid,if anything were to happen where i would need any med's from an accident or something? The medical staff of course would not know and may overdose me ACCIDENTLY. That is the reason i thought of an alternative way is to Detox, to see just how much crucial pain i can handle, for as i mentioned, It is going to be a long and difficult road, and even though the dose is high, I know i can (STOP). What concerns me is how much mobility will I have, for at times i can barely move my body and get around the Apt. with med's, but without, it will have to be one day at a time. Unfortunetly I reside in Toronto, Canada. Always wanted to Visit Washington. Maybe one day. Living on a fixed disability income i am not able to afford the cost of transportation and accomodations, to and from. Can - USA. Very sorry. If you have a company in Toronto? I would be interested in obtaining info on their studies if they have any. Or if your company could pave the way to Washington. That would be a very possitive approach, and could be feasable on my end. Personaly, I am a good candidate for what you want. Guaranty. Thank you very much, Ccg07
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