ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

CoQ10's Potential Capabilities for Your Health

Testosterone replacement therapy associated with improved urinary, sexual function

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

The Many Potential Health Benefits of Curcumin

Cinnamon Health Benefits Proven

8 Chia Seed Recipes

 
Print Page
Email Article

A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome – Source: Arthritis and Rheumatism, Sep 15, 2008

  [ 22 votes ]   [ Discuss This Article ]
By Nurcan Uceyler, et al. • www.ProHealth.com • September 24, 2008


[Note: This overview would not include research published since October 2007. Research published in August 2008, for example, reported “There is no evidence to support the efficacy of amitriptyline at higher doses or for periods [more than] 8 weeks” (http://www.prohealth.com//library/showarticle.cfm?libid=13851)]

Objective: To systematically review the efficacy of treatment of fibromyalgia syndrome (FMS) with antidepressants.

Methods: We screened Medline, PsychINFO, SCOPUS, and the Cochrane Library databases (through October 2007) and the reference sections of original studies, meta-analyses, and evidence-based guidelines and recommendations on antidepressants in FMS. Randomized controlled trials (RCTs) on the treatment of FMS with antidepressants were analyzed. Inclusion criteria, study characteristics, quality, and all outcome measures were investigated.

Results: Twenty-six of 167 studies were included. The main outcome variables reviewed were pain, fatigue, sleep, depressiveness, and quality of life.

Amitriptyline, studied in 13 RCTs, was efficient in reducing pain with a moderate magnitude of benefit (pain reduction by a mean of 26%, improvement in quality of life by 30%).

Selective serotonin reuptake inhibitors (SSRIs) were studied in 12 RCTs, which also showed positive results, except for 2 studies on citalopram and 1 on paroxetine.

Three RCTs on the dual serotonin and noradrenaline reuptake inhibitors (SNRIs) duloxetine and milnacipran and 1 of the 2 RCTs using the monoamine oxidase inhibitor moclobemide reported a positive result.

The longest study duration was 12 weeks.

Conclusion:
• Amitriptyline 25-50 mg/day reduces pain, fatigue, and depressiveness in patients with FMS and improves sleep and quality of life.
• Most SSRIs and the SNRIs duloxetine and milnacipran are probably also effective.
• Short-term treatment of patients with FMS using amitriptyline or another of the antidepressants that were effective in RCTs can be recommended.
• Data on long-term efficacy are lacking.

Source: Arthritis and Rheumatism, Sep 15, 2008;59(9):1279-98. PMID: 18759260, by Uçeyler N, Hauser W, Sommer C. University of Wurzburg, Wurzburg, Germany; Klinikum Saarbrucken, Saarbruken, Germany. [E-mail: sommer@uni-wuerzburg.de ]





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Breaking Through the Mental Fog Breaking Through the Mental Fog
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map