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Resolution of Syncope with Treatment of Sleep Apnea – Source: Journal of the American Board of Family Medicine, Sep-Oct 2008

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By Floyd B Willis, MD, Amber L Isley, MD, et al. • • September 25, 2008

[Note: The full text of this brief report is available free at It defines syncope/autonomic dysfunction, describes a case involving apnea-caused syncope and cognitive problems, and urges further study of an apnea/syncope connection.]

Sleep apnea is a common disorder associated with obesity and related health problems. Although treatment of sleep apnea may relieve some autonomic symptoms, it is currently unknown whether treatment of sleep apnea is specifically associated with the resolution of orthostatism and syncope.

Herein we describe a 73-year-old man who had recurrent episodes of syncope [low blood pressure/faintness when rising to an upright position]. An extensive work-up, including cardiac and neurologic consultations, failed to identify the cause.

An objective sleep evaluation led to the diagnosis of sleep apnea.

Accordingly, the patient was treated with continuous positive airway pressure [CPAP], which resolved the syncopal episodes.

This case report generates a potentially important hypothesis that recurrent syncope may be effectively treated, in part, by correcting apnea.

In patients with recurrent syncope of unknown etiology, a diagnosis of sleep apnea should be considered.

Source: Journal of the American board of Family Medicine, Oct 2008 21 (5): 466-468 (2008). PMID: 18772302, by Willis FB, Isley AL, Geda YE, Quarles L, Fredrickson PA. Departments of Family Medicine, Psychiatry and Psychology, Internal Medicine and Neurology, Mayo Clinic, Jacksonville, Florida; Division of Tertiary Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota. [E-mail: ]

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