ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

A Little Zinc Goes a Long Way

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

First pregabalin and now duloxetine for fibromyalgia syndrome: Closer to a brave new world? - Source: Nature Clinical Practice Rheumatology, Nov 4, 2008

  [ 11 votes ]   [ Discuss This Article ]
By Chad S Boomershine, MD, PhD • www.ProHealth.com • November 6, 2008


Fibromyalgia syndrome (FMS) is defined by the presence of chronic, widespread pain and tender points. Research implicating hypersensitization of central neural pathways in the pathogenesis of FMS pain has led to the development of medications that treat FMS by modulating synaptic activity, including duloxetine, milnacipran and pregabalin - all of which have undergone successful clinical trials. [Note: pregabalin (trade name Lyrica®) and duloxetine (Cymbalta®) have received FDA approval for treatment of fibromyalgia. Milnacipran® is under FDA review as an FM treatment.]

• Duloxetine and milnacipran are selective norepinephrine and serotonin reuptake inhibitors that improve pain by increasing the activity of antinociceptive pathways.

• Pregabalin is an alpha(2)delta calcium channel antagonist that reduces pain by limiting the release of excitatory neurotransmitters.

While treatment of FMS pain is important, effective FMS management requires identification and treatment of all symptoms experienced by individual FMS patients, which can include fatigue, insomnia, depression and anxiety.

Unfortunately, the lack of standardization in FMS trial design and controversy surrounding the disorder have complicated the development of integrated therapeutic regimens that could bring about a brave new world of effective management of FMS.

Source: Nature Clinical Practice Rheumatology, Nov 4, 2008. E-pub ahead of print. Boomershine CS, Outcomes Research, Vanderbilt Center for Integrative Health, Vanderbilt University, Nashville, Tennessee, USA. [E-mail: chad.boomershine@vanderbilt.edu]





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Safely Burn Away Body Fat Safely Burn Away Body Fat
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map