ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tea drinkers have lower glaucoma risk

Why Is Chlorella Considered a Superfood?

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Wonderful White Tea: A Drink Fit for an Emperor

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

Print Page
Email Article

First pregabalin and now duloxetine for fibromyalgia syndrome: Closer to a brave new world? - Source: Nature Clinical Practice Rheumatology, Nov 4, 2008

  [ 11 votes ]   [ Discuss This Article ]
By Chad S Boomershine, MD, PhD • • November 6, 2008

Fibromyalgia syndrome (FMS) is defined by the presence of chronic, widespread pain and tender points. Research implicating hypersensitization of central neural pathways in the pathogenesis of FMS pain has led to the development of medications that treat FMS by modulating synaptic activity, including duloxetine, milnacipran and pregabalin - all of which have undergone successful clinical trials. [Note: pregabalin (trade name Lyrica®) and duloxetine (Cymbalta®) have received FDA approval for treatment of fibromyalgia. Milnacipran® is under FDA review as an FM treatment.]

• Duloxetine and milnacipran are selective norepinephrine and serotonin reuptake inhibitors that improve pain by increasing the activity of antinociceptive pathways.

• Pregabalin is an alpha(2)delta calcium channel antagonist that reduces pain by limiting the release of excitatory neurotransmitters.

While treatment of FMS pain is important, effective FMS management requires identification and treatment of all symptoms experienced by individual FMS patients, which can include fatigue, insomnia, depression and anxiety.

Unfortunately, the lack of standardization in FMS trial design and controversy surrounding the disorder have complicated the development of integrated therapeutic regimens that could bring about a brave new world of effective management of FMS.

Source: Nature Clinical Practice Rheumatology, Nov 4, 2008. E-pub ahead of print. Boomershine CS, Outcomes Research, Vanderbilt Center for Integrative Health, Vanderbilt University, Nashville, Tennessee, USA. [E-mail:]

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil Optimized Curcumin Longvida®

Article Comments

Be the first to comment on this article!

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map