ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tea drinkers have lower glaucoma risk

Basic Aromatherapy to Help Balance and Calm

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Wonderful White Tea: A Drink Fit for an Emperor

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

 
Print Page
Email Article

Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms - Source: Current Opinion in Psychiatry, Jan 2009

  [ 55 votes ]   [ 2 Comments ]
By Michael Maes • www.ProHealth.com • January 9, 2009


[Note: oxidative and nitrosative stress pathways refer to complex series of biochemical reactions leading to harmful free radical and nitric oxide effects at the cellular level. LPS (lipopolysaccharide) is a component of certain bacteria normally confined to the intestine that may leak out due to infection.]

Purpose of Review The aim of this paper is to review recent findings on inflammatory and oxidative and nitrosative stress (IO&NS) pathways in chronic fatigue and somatization disorder.

Recent Findings
• Activation of oxidative and nitrosative stress (IO&NS) pathways is the key phenomenon underpinning chronic fatigue syndrome (CFS):

- Intracellular inflammation, with an increased production of nuclear factor kappa beta (NFkappabeta), cyclo-oxygenase-2 (COX-2) and inducible NO synthase (iNOS);

- And damage caused by O&NS to membrane fatty acids and functional proteins.

• These IO&NS pathways are induced by a number of trigger factors, for example: Psychological stress, strenuous exercise, viral infections, and an increased translocation of LPS from gram-bacteria (leaky gut).

• The 'psychosomatic' symptoms experienced by CFS patients are caused by:

- Intracellular inflammation (aches and pain, muscular tension, fatigue, irritability, sadness, and the subjective feeling of infection);

- Damage caused by O&NS (aches and pain, muscular tension and fatigue);

- And gut-derived inflammation (complaints of irritable bowel).

• Inflammatory pathways (monocytic activation) are also detected in somatizing disorder.

Summary:

• 'Functional' symptoms, as occurring in CFS and somatization, have a genuine organic cause, that is activation of peripheral and central IO&NS pathways and gut-derived inflammation.

• The development of new drugs, aimed at treating those disorders, should target these IO&NS pathways.

Source: Current Opinion in Psychiatry, Jan 2009;22(1):75-83. PMID: 19127706, by Maes M. Clinical Research Centre of Mental Health (CRC-MH), Antwerp, Belgium. [E-mail: crc.mh@telenet.be]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil FibroSleep™


Article Comments Post a Comment

significant step forward
Posted by: drewmanman
Jan 12, 2009
This review article is significant because it is published in a psychiatry journal, and the psychiatric community has often been skeptical that ME/CFS is an organic disorder. Hopefully this will help a lot of the skeptics to realize that there is something physically wrong with ME/CFS patients. Much of the groundbreaking research on the pathways described here has been done by Professor Martin Pall.
Reply Reply

Current Opinion in Psychiatry
Posted by: judimld
Jan 14, 2009
It is about time psychiatrists are becoming educated and learning more about CFS/FM/MCI. In the past many of them have created great hardships for patients suffering from those physiological illness and they caused many physically ill patients grief by testifying in the courtroom that these illness should be included as mental illnesses. I was one of those victims and lost everything due to psychiatrists' resistance to scientific research, out of their own lack of research and ignorance.
Reply Reply
 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Hydroxytyrosol: A Superior Antioxidant for Combatting Oxidative Stress Hydroxytyrosol: A Superior Antioxidant for Combatting Oxidative Stress

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map