ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

 
Print Page
Email Article

Central Nervous System Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome - Source: Pain Medicine, Feb 25, 2009

  [ 22 votes ]   [ Discuss This Article ]
By L. Becerra, PhD, David Borsook, MD, PhD, et al. • www.ProHealth.com • March 20, 2009


[Note: Complex regional pain syndrome is a rare disorder that involves intense pain in one limb, often followed by swelling, stiffness and muscle atrophy/contraction. It appears to be triggered by some illness, trauma, or injury that results in a disruption of central nervous system pain signalling relating to one part of the body.]

Background: Previous reports have indicated that ketamine anesthesia may produce significant improvement if not complete recovery of patients with complex regional pain syndrome (CRPS).

Aims: Here we report on a patient who had CRPS affecting mainly the right side of her body who underwent functional magnetic resonance imaging (fMRI) scans prior to and in the months following apparent successful treatment with anesthetic doses of ketamine.

Materials and Methods: The patient underwent two imaging sessions: one during her pain state (CRPS +) and 1 month after her ketamine treatment in her pain-free state (CRPS -).

Both spontaneous and evoked (brush, cold, and heat) pain scores decreased:
• From 7-9/10 on a visual analog scale prior to the treatment
• To 0-1 immediately following and for months after the treatment.

For each imaging session, the identical mechanical (brush) and thermal (cold and heat) stimuli were applied to the same location (the skin of the dorsum of the right hand).

Results:
Comparison of CRPS + vs CRPS - for the three stimuli showed significant changes:
• Throughout the cerebral cortex (frontal, parietal, temporal, cingulate, and hippocampus),
• In subcortical regions such as caudate nucleus,
• And in the cerebellum.

In addition:
• Resting state network analysis showed a reversal of brain network state,
• And the recovered state paralleled specific default networks in healthy volunteers.

Discussion: The observed changes in brain response to evoked stimuli provide a readout for the subjective response.

Conclusion: Future studies of brain function in these patients may provide novel insight into brain plasticity in response to this treatment for chronic pain.

Source: Pain Medicine, Feb 25, 2009. Becerra L, Schwartzman RJ, Kiefer RT, Rohr P, Moulton EA, Wallin D, Dendse G, Morris S, Borsook D. Pain/Analgesia Imaging Neuroscience (PAIN) Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts; Drexel University College of Medicine, Department of Neurology, Philadelphia, Pennsylvania, USA; Department of Anesthesiology and Intensive Care Medicine, Eberhard-Karls University, Tuebingen, Germany. [E-mail: David Borsook, MD, PhD, dborsook@partners.org]





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map