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Dalhousie University cancer researcher shows common virus kills cancer stem cells

  [ 17 votes ]   [ 1 Comment ] • April 26, 2009

“Human reovirus, a common virus that does not cause disease, effectively targets and kills cancer stem cells in breast cancer tissue… [and] stimulates the anti-cancer immune system.”

Halifax, Nova Scotia - Dalhousie Medical School cancer researcher Dr. Patrick Lee has proven that a common virus can infect and kill breast cancer stem cells. This breakthrough finding was published March 17 in Molecular Therapy, the prestigious journal of the American Society of Gene Therapy. [“Oncolytic Reovirus Effectively Targets Breast Cancer Stem Cells.”]

It is only within the past few years that the scientific community has understood the full significance of cancer stem cells and the urgent need to find a means of eliminating them.

“Cancer stem cells are essentially mother cells,” explains Dr. Lee, Cameron Chair in Basic Cancer Research at Dalhousie Medical School. “They continuously produce new cancer cells, aggressively forming tumors even when there are only a few of them.”

Cancer stem cells are difficult to kill as they respond poorly to chemotherapy and radiation.

As Dr. Lee notes, “You can kill all the regular cancer cells in a tumor, but as long as there are cancer stem cells present, disease will recur.”

Dr. Lee is optimistic that his team has found the key to destroying cancer stem cells. The researchers have recently shown that human reovirus, a common virus that does not cause disease, effectively targets and kills cancer stem cells in breast cancer tissue.

“We suspected that reovirus might be effective against cancer stem cells, because we have shown time and again how well it destroys regular cancer cells,” remarks Dr. Lee, who was the first in the world to discover that a benign and naturally occurring virus could selectively infect and kill cancer cells without harming healthy cells.

A Calgary-based company, Oncolytics Biotech Inc., is testing reovirus in human clinical trials to prove the treatments are safe and effective.

Unlike most cancer studies, which use cancer cell lines developed for laboratory use, this study used fresh breast cancer tissue. This cancer tissue was removed from a patient of Dr. Carman Giacomantonio, a Capital Health surgical oncologist who is working with Dr. Lee on the reovirus research, along with post-doctoral fellow Dr. Paola Marcato and research assistant Cheryl Dean.

In addition to its ability to kill cancer cells and cancer stem cells, reovirus stimulates the anti-cancer immune system. Since virus therapy also invokes an anti-virus response, Dr. Lee and post-doctoral fellow Dr. Shashi Gujar are working on a way to harness the immune system so it attacks cancer cells while allowing the virus to freely infect and destroy cancerous cells. “Refining this two-pronged approach to killing cancer is our next step,” says Dr. Lee. “We are taking advantage of the natural characteristics of reovirus and the immune system itself to create a powerful virus-based anti-cancer therapy.”

Dr. Lee’s discovery that reovirus effectively targets breast cancer stem cells has captured the attention of LeadDiscovery, a UK-based organization dedicated to promoting drug discovery and development.

LeadDiscovery has identified the finding to be of particular interest to the drug development sector and will feature it in its next update to the global scientific community and pharmaceutical industry.

Dr. Patrick Lee is a founding member of the Beatrice Hunter Cancer Research Institute, established on April 2, 2009 to foster a coordinated cancer research effort in Atlantic Canada. The institute was named in honor of the late Beatrice Hunter, whose $12.5 million gift to the Dalhousie Medical Research Foundation transformed cancer research in the region...

Source: Dalhousie University news release Apr 7, 2009. [E-mail: Dr. Patrick Lee]

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Article Comments Post a Comment

Cancer Cure?
Posted by: Svette_Palme
May 14, 2009
It seems to me that this is very good news in cancer research. Killing the cancer stem cells might be the holy grail of cancer cures, since many cancers spreads even after a successful treatment of a particular tumor, which renders most cancer treatments as being "just a little help". That the agent happens to be a virus adds to the mystery of human health. Maybe we need some viruses, just like we need many bacterial strains [of our total cell count, 90% belong to bacterial strains and other outside cells, only 10% are human cells]. Maybe killing viruses has led to cancers? I think this research opens up many questions.
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