ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Restoring NAD+ could reduce DNA damage accumulation

 
Print Page
Email Article

Researchers identify key to immune system success - or failure - in chronic viral infection control

  [ Not Yet Rated ]   [ Discuss This Article ]
www.ProHealth.com • May 14, 2009


“Interleukin-21 is a critical player in the body's fight against chronic infection.... These immune cells are running a long-distance race to contain the virus before it spreads. If they don't get fed, they collapse on the track."

Why is the immune system able to fight off some viruses but not others, leading to chronic, life-threatening infections like HIV and hepatitis C?

A new UCLA AIDS Institute study suggests the answer lies in a protein called interleukin-21 (IL-21), a powerful molecule released by immune cells during chronic infection. Published May 7 in the online edition of Science [See “IL-21 is required to control chronic viral infection”], the finding could explain how the immune system limits viral replication, restricting a virus's spread through the body.

The researchers looked at two types of T-cells - CD4 T-cells and CD8 T-cells - which are immune cells that play an important role in the body's response to infection. The CD4 T-cells help the immune system by producing IL-21 during chronic infection, bolstering the CD8 T-cells' ability to fight off the virus.

"The CD4 cells are the regulators - the generals, if you will," said principal investigator David Brooks, assistant professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. "The CD8 cells go out and kill the invaders; they're like the privates in the field."

To shed light on how CD4 T-cells help their CD8 counterparts clear viruses, the researchers infected mice with one of two strains of a virus. They knew that the first strain would generate a short-term infection and the second a chronic infection.

The scientists tested each strain on two groups of mice. One group was normal and the other was bred without IL-21 receptors.

In the normal mice, the first strain elicited a strong T-cell response that completely eliminated the virus in 10 days. The second strain caused a chronic infection that exhausted the T-cells, hampering their ability to fight the virus. The UCLA team detected high levels of IL-21 in these mice, suggesting that the protein plays a crucial role in sustaining the T-cells' ability to mount an immune response during long-lasting infection.

When the scientists infected the mice that lacked IL-21 receptors with the chronic infection strain, something curious happened. The majority of virus-fighting CD8 T-cells disappeared, preventing the immune system from containing the spread of the virus.

"IL-21 fuels CD8 T-cells' ability to function," Brooks said. "These immune cells are running a long-distance race to contain the virus before it spreads. If they don't get fed, they collapse on the track." Without IL-21, the CD8 T-cells dwindled, even when the CD4 T-cells produced a robust response. The result indicates that the T-cells rely on IL-21 to resolve persistent infection.

"After the immune system loses CD8 T-cells, it's unable to clear the virus," Brooks said. "This tells us that IL-21 is a critical player in the body's fight against chronic infection."

The study was funded by the UCLA Center for AIDS Research, the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, and the National Institutes of Health. Brooks' co-authors included Heidi Elsaesser of UCLA and Karsten Sauer of the Scripps Research Institute

Source: UCLA news release, May 7, 2009




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map