ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Higher vitamin D levels associated with less severe disease in NAFLD patients

Can Pomegranates Slow Aging?

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

What Benefits Can You Get From High-Quality Whey Protein?

 
Print Page
Email Article

Elevated Triglycerides Correlate with Progression of Diabetic Neuropathy – Source: Diabetes, May 1, 2009

  [ 37 votes ]   [ Discuss This Article ]
By Timothy D Wiggin, Eva L Feldman, et al. • www.ProHealth.com • May 30, 2009


Objective: To evaluate mechanisms underlying diabetic neuropathy (DN) progression using indices of sural nerve morphometry obtained from two identical randomized placebo-controlled clinical trials.

Research Design and Methods: Sural nerve myelinated fiber density (MFD), nerve conduction velocities, vibration perception thresholds, clinical symptom scores and a visual analogue scale for pain were analyzed in participants with DN. A losee of 500 or more fibers/mm(2) in sural nerve MFD over 52 weeks was defined as progressing DN and a MFD loss of 100 or less fibers/mm(2) during the same time interval as non-progressing DN. The progressing and non-progressing cohorts were matched for baseline characteristics using an O'Brien rank sum and baseline MFD.

Results:

• At 52 weeks, the progressing cohort demonstrated a 25% decrease (p < 0.0001) from baseline in myelinated fiber density while the non-progressing cohort remained unchanged.

• Myelinated fiber density was not affected by active drug treatment (p=0.87), diabetes duration (p=0.48), age (p=0.11) or body mass index (BMI) (p=0.30).

• Among all variables tested, elevated triglycerides and decreased peroneal motor NCV at baseline significantly correlated with loss of myelinated fiber density at 52 weeks (p=0.04).

Conclusions: In this cohort of participants with mild/moderate DN, elevated triglycerides correlated with myelinated fiber density loss independent of disease duration, age, diabetes control or other variables. [Note: Dietitians advise that triglycerides, made in the liver from excess sugar not used for energy production, may be controlled by eliminating simple sugar in the diet.]

These data support the evolving concept that hyperlipidemia is instrumental in the progression of diabetic neuropathy.

Source: Diabetes, May 1, 2009. PMID: 19411614, by Wiggin TD, Sullivan KA, Pop-Busui R, Amato A, Sima AA, Feldman EL. University of Michigan Department of Neurology. [E-mail: efeldman@umich.edu]





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Live Without Anxiety or Stress Live Without Anxiety or Stress
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map