ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

 
Print Page
Email Article

Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells – Source: American Journal of Clinical Nutrition, Aug 2009

  [ 30 votes ]   [ Discuss This Article ]
By Mark Bouwens, Lydia Afman, et al. • www.ProHealth.com • July 30, 2009


[Note: peripheral blood mononuclear cells are infection fighting components of the immune system.]

Background: Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown.

Objective: The objective was to examine the effects of supplementation with the polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on whole-genome PBMC gene expression profiles, in healthy Dutch elderly subjects participating in a double-blind trial, by using whole-genome transcriptomics analysis.

Design: The subjects were randomly allocated to 1 of 3 groups:

1. Consumption of 1.8 g EPA+DHA/d (n = 36),

2. Consumption of 0.4 g EPA+DHA/d (n = 37), or

3. Consumption of 4.0 g high-oleic acid sunflower oil (HOSF)/d (n = 38).

All supplements were given in capsules. Before and after 26 weeks of intervention, blood samples were collected. Microarray analysis was performed on PBMC RNA from 23 subjects who received 1.8 g EPA+DHA/d and 25 subjects who received HOSF capsules. Quantitative real-time polymerase chain reaction was performed in all 111 subjects.

Results:

• A high EPA+DHA intake changed the expression of 1040 genes, whereas high-oleic acid sunflower oil intake changed the expression of only 298 genes.

• EPA+DHA intake resulted in a decreased expression of genes involved in inflammatory- and atherogenic-related [plaque forming] pathways, such as nuclear transcription factor kappaB signaling, eicosanoid synthesis, scavenger receptor activity, adipogenesis, and hypoxia signaling.

Conclusion: These results are the first to show that intake of EPA+DHA for 26 weeks can alter the gene expression profiles of peripheral blood mononuclear cells to a more antiinflammatory and antiatherogenic status. This trial was registered at clinicaltrials.gov as NCT00124852 ["The efficacy of omega-3 fatty acids in maintaining optimal mental health in elderly people."]

Source: American Journal of Clinical Nutrition, Aug 2009. PMID: 19515734, by Bouwens M, van de Rest O, Dellschaft N, Grootte Bromhaar M, de Groot L, Geleijnse JM, Muller M, Afman LA. Nutrition, Metabolism & Genomics Group and Nutrition & Health Group, Division of Human Nutrition, Wageningen University; Nutrigenomics Consortium, Top Institute Food & Nutrition, Wageningen, Netherlands. [E-mail: lydia.afman@wur.nl]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map