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Understanding fibromyalgia: Lessons from the broader pain research community – Source: Journal of Pain, Aug 2009

  [ 7 votes ]   [ 2 Comments ]
By David A Williams, Daniel J Clauw • • July 31, 2009

Fibromyalgia (FM) is a chronic pain condition marked by centrally mediated augmentation of pain and sensory processes. Skepticism has marked the history of this condition, but more recent study has identified neurobiological underpinnings supporting many of the symptoms associated with this condition.
Early research in FM had unprecedented latitude within the rheumatology community to borrow heavily from theory and methods being applied in chronic pain research more generally. These insights facilitated rapid advances in FM research, not the least of which was the abandonment of a peripheral focus in favor of studying central [nervous system] mechanisms associated with central augmentation.

Currently, rapid-paced discovery is taking place in FM genetics, patient assessment, new therapeutic targets, and novel methods of treatment delivery.

Such insights are not likely to be limited in application just to FM and could have relevance to the broader field of pain research as well.

Perspective: This manuscript reviews:
• The history of FM and its diagnosis,
• Evidence supporting central augmentation of pain in FM,
• Potential mechanisms of central augmentation,
• Current approaches to integrated care of FM,
• And areas of active collaboration between FM research and other chronic pain conditions.

Source: Journal of Pain, Aug 2009;10(8):777-91. PMID: 19638325, by Williams DA, Clauw DJ.Chronic Pain and Fatigue Research Center, The University of Michigan, Ann Arbor, Michigan, USA. [E-mail:]

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Article Comments Post a Comment

About time~
Posted by: glenda*sue
Aug 14, 2009
About time someone is treating and investigating FMS with an eye toward a physical reason.. Most of us could have told you before :)
Reply Reply

Already plenty of evidence
Posted by: wentworth228
Aug 17, 2009
Dr Mohammed Yunus in Peoria, the godfather of FMS has already documented plenty of chemical abnormalities in people who have Fibro. Ihave not seen the article, but I am sure he will be mentioned.


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