ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

More evidence for calorie restriction’s longevity effect

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Clinical and neurobiological correlates of DXS1047 genotype in Alzheimer's disease.

  [ Not Yet Rated ]   [ Discuss This Article ]
By Zubenko GS, Hughes HB, Stiffler JS • www.ProHealth.com • July 15, 1999


BACKGROUND: The goal of the current study was to explore the clinical, neuropathological, and neurochemical correlates of the DXS1047 202 bp allele in a group of 50 autopsy-confirmed cases of Alzheimer's disease (AD) who lacked other concomitant brain diseases. We previously published the results of a genome survey for novel risk loci for typical-onset (> or = 60 years) AD conducted at 10 cM resolution (Zubenko et al 1998a, b). This survey detected associations of alleles at six microsatellite loci with AD, including the 202 bp allele of the DXS1047 locus that resides within Xq25 on the human cytogenetic map.

METHODS: Clinical assessments were performed as part of a longitudinal study of AD and related disorders. Autopsies were performed using standardized methods and the resulting diagnoses were made according to established criteria. Genotyping, morphometry, and neurochemical analyses were performed using postmortem brain tissue.

RESULTS: Patients with AD who carried the DXS1047 202 bp allele manifested cortical norepinephrine levels that ranged from 2.1 to 3.6 times the corresponding values for noncarriers (p = .002), controlling for the potential effects of gender, age at symptomatic onset or death, and postmortem interval. In contrast, carriers tended to have lower cortical levels of dopamine (p = .10).

CONCLUSIONS: These findings support the results of our previous genome survey and suggest that the DXS1047 locus, or a locus in close proximity, modulates biological variables relevant to the pathophysiology of AD. In addition to providing insights into the clinical biology of AD, the characterization of biologically meaningful subtypes, including genotypic subtypes associated with particular neurobiological derangements, may be important to the advancement of experimental therapeutics in AD.

Source: Biol Psychiatry 1999 Jul 15;46(2):173-81
PMID: 10418691, UI: 99347245

(Department of Psychiatry, School of Medicine, University of Pittsburgh, PA, USA.)







Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map