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Alzheimer’s study using grapeseed extract finds plaque-fighting polyphenols do reach the brain with sustained supplementation

  [ 25 votes ]   [ Discuss This Article ] • August 20, 2009

“Reasonable and chronic consumption of these products may be the way to go, rather than single, high doses, similar to drugs. It's like eating an apple a day, not a case of apples over two days every month." – Giulio Pasinetti, MD, Mount Sinai School of Medicine

The polyphenols found in red wine and the skins and seeds of grapes are thought to help prevent Alzheimer's disease, and new research from Purdue University and Mount Sinai School of Medicine has shown that some of those compounds in fact reach the brain.

In fact, the researchers found that the amount of polyphenols from grapeseed extract that can reach a rat's brain is as much as 200 percent higher on the 10th consecutive day of feeding than on the first.

• Many previous experiments, in which absorption was measured after single or sporadic doses, often found very little, if any, of the bioactive polyphenols reaching brain tissues.

• However, more chronic exposure appears to improve absorption.

"This shows that reasonable and chronic consumption of these products may be the way to go, rather than single, high doses, similar to drugs," said Dr. Mario Ferruzzi, PhD, a Purdue associate professor of food science, who collaborated on the research with Mount Sinai's Dr. Giulio Pasinetti, MD. "It's like eating an apple a day, not a case of apples over two days every month."

A paper detailing the findings was published online Aug 20 in the Journal of Alzheimer's Disease.(1)

Polyphenols, compounds found in the skins and seeds of grapes, are thought to prevent the formation of beta-amyloid protein, which creates the plaque in the brain that causes Alzheimer's disease.

Alzheimer's is a progressive brain disease that destroys memory and cognitive skills and affects as many as 4.5 million Americans, according to the National Institute on Aging. Dr. Pasinetti (the Aidekman Family Professor in Neurology and director of the Center of Excellence for Novel Approaches to Neurotherapeutics) said discovering how polyphenols are absorbed and distributed to the brain can impact researchers' understanding of the amount of grape products or red wine a person would need to consume to most effectively combat Alzheimer's disease.

"The most important thing is that when we follow the repetitive administration of this compound, we were able to observe the transfer of the compound to the brain," Dr. Pasinetti said. "This may help us figure out the proper concentration necessary to get these chemicals to the brain."

Dr. Ferruzzi said the study dealt with polyphenols, but also could be important for determining proper doses of other compounds or drugs for patients.

Testing of a pharmaceutical, for example, could show that the drug is too potent when given repetitively; whereas that might not be apparent if the drug is administered on non-consecutive days or weeks.

"It could become important in terms of side effects," Dr. Ferruzzi said. "You could be overdosing because the body is adapting and absorbing or metabolizing these compounds differently over time." Further studies will focus on the mechanisms that control absorption of compounds during chronic consumption.
1. Article cited: “Bioavailability of Gallic Acid and Catechins from Grape Seed Polyphenol Extract is improved by repeated dosing in rats: Implications for treatment in Alzheimer’s disease,” Journal of Alzheimer’s Disease, Jul 20, 2009

Source: Purdue University news release, Aug 19, 2009

Note: This information has not been evaluated by the FDA. It is general and is not intended to prevent, diagnose, treat or cure any illness, condition, or disease. It is important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.

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