ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

Probiotics improve cognition in Alzheimer's patients

The Onion: Cancer Fighter and Food Preserver

Print Page
Email Article

Increased glutamate-glutamine compounds (Glx) in the brain of patients with fibromyalgia: A MR spectroscopy study – Source: Arthritis and Rheumatism, Feb 26, 2010

  [ 21 votes ]   [ Discuss This Article ]
By Manuel Valdes, MD, et al. • • March 2, 2010

Fibromyalgia (FM) has been defined as a systemic disorder clinically characterized by pain, cognitive deficit and the presence of associated psychopathology, all of which are suggestive of a primary brain dysfunction.

In order to identify the nature of this cerebral dysfunction, brain metabolites of FM patients have been studied through MR spectroscopy techniques.

Methods: Brain metabolites in amygdala, thalami and prefrontal cortex were studied through MR spectroscopy techniques in a sample of 28 women with FM, and in a control group of healthy women (n=24) of the same age.

Results: Compared to healthy controls FM patients showed:

• Higher levels of glutamate compounds (Glx) (11,9+/-1,6 vs 13,4+/-1,7 arbitrary institutional units respectively, t= 2.517, df 35, p=0.03)

• And a higher glutamine-glutamate/creatine ratio (Glx/Cr) (2,1+/- 0,4 in controls vs 2,4 +/- 1,4 in FM patients, t=2.373, df 35, p=0.04) in the right amygdala.

In FM patients with more pain, fatigue and depressive symptoms, inositol (Ins) levels were significantly higher in the right amygdala and right thalamus.

Conclusions: The distinctive metabolic features found in the right amygdala of FM patients suggest the possible existence of a neural dysfunction in emotional processing, this being a prolongation of the dysfunction in pain processing previously proposed by some authors.

Source: Arthritis and Rheumatism, Feb 26, 2010. PMID: 20191578, by Valdés M, Collado A, Bargalló N, Vázquez M, Rami L, Gómez E, Salamero M. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Safely Burn Away Body Fat Safely Burn Away Body Fat

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map