ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

Drug Effective for Treatment of Rheumatoid Arthritis, With Fewer Side-Effects

  [ Not Yet Rated ]   [ Discuss This Article ]
By News Release • www.ProHealth.com • January 18, 2000


SUMMARY: Two anti-inflammatory agents (celecoxib and naproxen) have been found to be effective at providing pain relief and anti-inflammatory relief from arthritis while minimizing gastrointestinal (GI) side effects. Celecoxib is significantly easier on the GI system than naproxen.

CHICAGO, IL -- Two anti-inflammatory agents have been found to be effective at providing pain relief and anti-inflammatory relief from arthritis while minimizing gastrointestinal (GI) side effects, according to articles in the November 24 issue of The Journal of the American Medical Association (JAMA).

Dr. Lee S. Simon, from Beth Israel Deaconess Medical Center and Harvard Medical School in Boston and colleagues analyzed whether the drug celecoxib reduces the incidence of GI mucosal damage compared with conventional nonsteroidal anti-inflammatory drugs (NSAIDs) in a randomized controlled, clinical trial.

Patients in the 12 week study at 79 clinical sites were randomly assigned to receive twice per day 100 milligrams (mg.), 200 mg., or 400 mg. of celecoxib or 500 mg. of naproxen (a NSAID) twice per day, or a placebo. All doses of celecoxib and naproxen improved the signs and symptoms of arthritis. The incidence, however, of gastroduodenal ulcers determined by using an endoscope was:
-- 4 percent (4 of 99) of patients receiving placebo
-- 6 percent (9 of 148) of patients receiving 100 mg. (twice a day) of celecoxib
-- 4 percent (6 of 145) of patients receiving 200 mg. (twice a day) of celecoxib
-- 6 percent (8 of 130) of patients receiving 400 mg. (twice a day) of celecoxib
-- 26 percent (36 of 137) of patients receiving 500 mg. (twice a day) of naproxen

"Celecoxib produced improvement in the signs and symptoms of rheumatoid arthritis comparable with the effects of naproxen but with a significantly reduced incidence of endoscopically identified gastroduodenal ulcers" the authors write. "Thus, one of the major impediments that can limit the effective use of conventional NSAIDs, upper GI tract toxic effects, may potentially be obviated by the use of celecoxib."

Celecoxib is an anti-inflammatory agent that inhibits cyclooxygenase 2 (COX-2) enzymes while allowing normal activity of cyclooxygenase 1 (COX-1) enzymes. According to the authors, celecoxib was effective at all doses studied at providing pain relief and anti-inflammatory relief while reducing the GI side effects more than naproxen, an anti-inflammatory agent that inhibits both COX-1 and COX-2 enzymes.

Citing other studies, the authors note that approximately 20 percent to 30 percent of patients develop persistent adverse effects from conventional NSAID therapy, with more than 10 percent discontinuing treatment. "It is well established that conventional NSAID therapy can lead to gastroduodenal ulceration and associated serious complications of perforation, hemorrhage and gastric outlet obstruction. There is evidence to suggest that NSAID-induced ulcers and their resulting complications are largely caused by NSAID-mediated inhibition of mucosal prostaglandin [prostaglandins are fatty acids that act in a similar way to hormones] production, primarily mediated by COX-1 activity. Prostaglandins have been shown to modulate gastroduodenal mucosal protection by several interrelated mechanisms." (JAMA. 1999;282:1921-1928)

Source: The



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map