ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

Probiotics improve cognition in Alzheimer's patients

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Cause-Specific Cardiovascular Risk Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals – Source: Circulation: Cardiovascular Quality and Outcomes, Jun 8, 2010

  [ 147 votes ]   [ Discuss This Article ]
By Emil Loldrup Fosbøl, et al. • www.ProHealth.com • June 10, 2010


Background: Studies have raised concern on the cardiovascular safety of nonsteroidal antiinflammatory drugs (NSAIDs). We studied safety of NSAID therapy in a nationwide cohort of healthy individuals.

Methods and Results:
With the use of individual-level linkage of nationwide administrative registers, we identified a cohort of individuals without hospitalizations 5 years before first prescription claim of NSAIDs and without claimed drug prescriptions for selected concomitant medication 2 years previously.

The risk of cardiovascular death, a composite of coronary death or nonfatal myocardial infarction, and fatal or nonfatal stroke associated with the use of NSAIDs was estimated by case-crossover and Cox proportional hazard analyses.

The entire Danish population age 10 years or more consisted of 4,614,807 individuals on January 1, 1997, of which 2,663,706 (57.8%) claimed at least 1 prescription for NSAIDs during 1997 to 2005.

Of these; 1,028,437 individuals were included in the study after applying selection criteria regarding comorbidity and concomitant pharmacotherapy.

• Use of the nonselective NSAID diclofenac [sold under more than 30 trade names] and the selective cyclooxygenase-2 inhibitor rofecoxib [aka Vioxx, withdrawn from the market in 2004] was associated with an increased risk of cardiovascular death (odds ratio, 1.91; 95% confidence interval, 1.62 to 2.42 [91% greater average risk of cardiovascular death with diclofenac]; and odds ratio, 1.66; 95% confidence interval, 1.06 to 2.59, respectively) [66% greater average risk with Vioxx]…

…with a dose-dependent increase in risk. [Higher dose, more risk.]

• There was a trend for increased risk of fatal or nonfatal stroke associated with ibuprofen treatment (odds ratio, 1.29; 95% confidence interval, 1.02 to 1.63) [29% average increase in risk of stroke],

• But naproxen (aka Aleve) was not associated with increased cardiovascular risk (odds ratio for cardiovascular death, 0.84; 95% confidence interval, 0.50 to 1.42) [16% lower average risk].

Conclusions: Individual NSAIDs have different degrees of cardiovascular safety, which must be considered when choosing appropriate treatment.

In particular:

• Rofecoxib and diclofenac were associated with increased cardiovascular mortality and morbidity and should be used with caution in most individuals,

• Whereas our results suggest that naproxen has a safer cardiovascular risk-profile. [But apparently also entails risk of GI bleeding/ulcers because it inhibits both COX-2 (inflammation promoting enzyme) and COX-1 (stomach lining protective enzyme).]

Source: Circulation: Cardiovascular Quality and Outcomes, Jun 8, 2010. PMID: 20530789, by Fosbol L, Jacobsen S, Rasmussen J, Sorensen R, Schramm T, Andersen S, Rasmussen S, Poulsen H, Kober L, Torp-Pedersen C, Gislason G. Department of Cardiology, Gentofte University Hospital, Hellerup; Departments of Rheumatology and Clinical Pharmacology, and The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen; National Institute of Public Health, Copenhagen, Denmark. [Email: ELF@heart.dk]





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Live Without Anxiety or Stress Live Without Anxiety or Stress
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map