ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

Print Page
Email Article

Pregabalin [Lyrica®] in fibromyalgia - Responder analysis from individual patient data – Source: BMC Musculoskeletal Disorders, Jul 5, 2010

  [ 115 votes ]   [ 5 Comments ]
By Sebastian Straube, et al. • • July 5, 2010

[Note: to read the full text of this article free click here. "Number needed to treat" represents the number of subjects who would need to be treated for one to achieve a greater benefit (e.g., 50% greater, considered significantly greater in this analysis) than those taking placebo in a clinical trial.]

Background: Population mean [average] changes are difficult to use in clinical practice. Responder analysis may be better, but needs validating for level of response and treatment duration. A consensus group has defined what constitutes minimal, moderate, and substantial benefit based on pain intensity and Patient Global Impression of Change scores.

Methods: We obtained individual patient data from four randomized double blind trials of pregabalin [Lyrica] in fibromyalgia lasting 8 to 14 weeks.

We calculated response for all efficacy outcomes using:

•  Any improvement ([greater than or equal to] 0%),

•  Minimal improvement ([greater than or equal to]15%),

•  Moderate improvement ([greater than or equal to] 30%),

•  Substantial improvement ([greater than or equal to] 50%), and

•  Extensive improvement ([greater than or equal to]70%)...

with numbers needed to treat (NNT) for pregabalin 300 mg, 450 mg, and 600 mg daily compared with placebo.

Results: Information from 2,757 patients was available.

Pain intensity and sleep interference showed reductions with increasing level of response, a significant difference between pregabalin and placebo, and a trend towards lower (better) NNTs at higher doses.

Maximum response rates occurred at 4-6 weeks for higher levels of response, and were constant thereafter.

Numbers needed to treat (with 95% confidence intervals) for [greater than or equal to]50% improvement in pain intensity compared with placebo after 12 weeks were:

•  22 (11 to 870) for pregabalin 300 mg, [that is, one in 22 patients taking this dose would achieve a "substantial improvement" in pain of 50% or more above those taking fake dose/placebo]

•  16 (9.3 to 59) for pregabalin 450 mg, and

•  13 (8.1 to 31) for pregabalin 600 mg daily.

Numbers needed to treat for [greater than or equal to]50% improvement in sleep interference compared with placebo after 12 weeks were:

•  13 (8.2 to 30) for pregabalin 300 mg,[that is one in 13 patients taking this dose would achieve a "substantial" 50% or more improvement in sleep above those taking fake dose/placebo]

•  8.4 (6.0 to 14) for pregabalin 450 mg, and

•  8.4 (6.1 to 14) for pregabalin 600 mg.

Other outcomes had fewer respondents at higher response levels, but generally did not discriminate between pregabalin and placebo, or show any dose response.

Shorter duration and use of 'any improvement' over-estimated treatment effect compared with longer duration and higher levels of response.

Conclusions: Responder analysis is useful in fibromyalgia, particularly for pain and sleep outcomes. Some fibromyalgia patients treated with pregabalin experience a moderate or substantial pain response that is consistent over time.

Short trials using 'any improvement' as an outcome overestimate treatment effects.

Source: BMC [BioMedCentral] Musculoskeletal Disorders, Jul 5, 2010;11:150. DOI:10.1186/1471-2474-11-150, by Straube S, Derry S, Moore RA, Paine J, McQuay HJ. Department of Occupational and Social Medicine, University of Göttingen, Germany and Pain Research and Nuffield Department of Anesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK. [Email]

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®

Article Comments Post a Comment

Lyrica trials
Posted by: smeyers
Jul 14, 2010
I'm sorry but I don't understand this article at all. It seems to me it just says how many people were needed/used in the study - not what their results were. I tried Lyrica and it didn't work at all for me. In fact, I had to quit because it was making me really depressed. I couldn't tell from your article how many people had a good outcome from trying this medication. Susan
Reply Reply

Posted by: harboreen
Jul 16, 2010
I'm not sure I get this article either but I wanted to respond to your comment smeyer. I too had to stop taking Lyrica due to depression which I did not have prior to using this med. It got rapidly worse as the days passed so after two months I went off Lyrica. It's strange because I went back to using neurontin/gabapentin which does help my fibromyalgia pain although I do not use this soley for pain.


Posted by: JulieL
Jul 14, 2010
I agree with the previous lady. I don't understand what the outcomes where for the people taking Lyrica. I started taking Lyrica about 2 1/2 months ago and I felt good for about 2 weeks. It has been down hill since. I am taking the lowest amt so I will need to speak to my doctor next month on my visit to see what she says.
Reply Reply

Posted by: amiller1914
Jul 21, 2010
Side effects not worth the limited results. It increased my swelling and inflammation. Weight can has led to plantafacitis.
Reply Reply

useful article
Posted by: FMoldtimer
Aug 1, 2010
The point of the article--depending on the effect you're looking at, only roughly 1 in 13, 1 in 8.4 etc. people will see a significant result. On the whole, that means Lyrica may help some folks with FM, but not all, or even very many. That's what "number needed to treat" is all about.

That said, I've had modest success with the lowest possible dose, 75 mg, used primarily as a sleep aid. I'm combining that with 75 mg of nortriptyline. I won't say my sleep is always great, but it's better than with just the nortriptyline. When I took higher doses of that, I was just hung over the next day. I don't think the Lyrica is helping with pain per se, but better sleep generally leads to less pain, at least for me.


Post a Comment

Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Breaking Through the Mental Fog Breaking Through the Mental Fog

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map