ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Close analysis of a large published cohort trial into fatigue syndromes and mood disorders that occur after documented viral infection – Source: Bulletin of the IACFS/ME, Summer 2010

  [ 10 votes ]   [ 1 Comment ]
By David P Sampson • www.ProHealth.com • September 10, 2010


[Note: to read the full text of this article free, click HERE.]

This paper presents a close analysis of a large published cohort trial into predictors (risk factors) for developing a fatigue syndrome or mood disorder following either infectious mononucleosis or an upper respiratory tract infection - White et al. *

Critically, in addition to utilizing broad based definitions of ME/CFS, such as the Oxford and CDC CFS criteria, White et al also utilize a further definition, Empirical Fatigue Syndrome, which excludes current psychiatric illness.

This provides important additional insights into the results, leading to conclusions which are materially different to those that the author draws, in relation to the inherent validity of broad based definitions of CFS and in relation to the significance of deconditioning as a perpetuating factor in this illness.

• Examination of the data shows that the highest risk factor for developing a non-psychiatrically defined Fatigue Syndrome (i.e. Empirical Fatigue Syndrome), even 6 months later, is documented clinical evidence of viral infection (infectious mononucleosis), not previous psychiatric morbidity.

• Furthermore under the Empirical definition, no significant correlation exists between bed rest at onset and subsequent development of a fatigue syndrome; this suggests that deconditioning is not an important perpetuating factor under this definition.

• Conversely, wider definitions of ME/CFS that do not exclude individuals with psychological/psychiatric reasons for their fatigue (such as the Oxford and CDC criteria):

• Reduce the importance of clinical factors (infectious mononucleosis)

• And increase the importance of  factors such as GP attendance in year before onset, mood disorder at 2 months, and past psychiatric illness, which are consistent predictors of subsequent mood disorder quite independently of the existence or otherwise of a fatigue syndrome.

This analysis and the original data in the White et al. paper strongly calls into question the validity of broad based definitions of ME/CFS, such as the Oxford (and to lesser extent CDC) criteria. [bolding ours]

This is in large part due to the clear inclusion within such criteria of significant numbers of patients with primarily mood disorder/psychiatric illness in addition to those with ME/CFS.

Source: Bulletin of the IACFS/ME, Summer 2010;18(2):44-81, Sampson DP, et al. [Email: davidsamps@aol.com]
____

* “Predictions and associations of fatigue syndromes and mood disorders that occur after infectious mononucleosis” http://www.ncbi.nlm.nih.gov/pubmed/11747919 Lancet, Dec 2001





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Mitochondria Ignite™ with NT Factor®


Article Comments Post a Comment

All must use Jason Mod Canadian criteria
Posted by: IanH
Sep 11, 2010
This is why every researcher and clinician should use the modified Canadian criteria for ME/CFS by Prof. Leonard Jason (De Paul University). Any studies not using these criteria, especially those using Fukuda or Oxford criteria should be rejected by Journals on the basis of weak case definition and therefore unreliable cohort. This may sound tough but some consistency will help the quality of research and advancement of knowledge.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3 Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map