ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells

German Chamomile Oil: A Versatile Essential Oil You Should Have at Home

 
Print Page
Email Article

Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms – Source: PLoS One, Sep 14, 2010

  [ 4 votes ]   [ Discuss This Article ]
By Thibaud Lebouvier, et al. • www.ProHealth.com • September 17, 2010


[Note: to read the full text of this article free, click HERE.  Lewy bodies/neurites are abnormal protein clumps that develop inside the nerve cells of Parkinson’s patients – both in the brain and, as this study of colon biopsies demonstrates, in the enteric nervous system (which directly controls the gastrointestinal system).]

Background: The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients.
 
The aims of the present research were to use routine colonoscopy biopsies:

1. To analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP) [tissue containing nerves, blood and lymphatic vessels supplying the mucous lining], and

2. To correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.

Methodology/Principal Findings: A total of 10 control and 29 PD patients divided into 3 groups according to disease duration were included. PD and GI symptoms were assessed using the Unified Parkinson's Disease Rating Scale part III and the Rome III questionnaire, respectively. Four biopsies were taken from the ascending and descending colon during the course of a total colonoscopy.

Immunohistochemical analysis was performed using antibodies against phosphorylated alpha-synuclein, neurofilaments NF 220 kDa (NF) and tyrosine hydroxylase (TH).

The density of LN, labeled by anti-phosphorylated alpha-synuclein antibodies, was evaluated using a quantitative rating score.

Lewy pathology was apparent in the colonic biopsies from 21 patients and in none of the controls.

A decreased number of NF-immunoreactive neurons per ganglion was observed in the SMP of PD patients compared to controls.

The amount of LN in the ENS was inversely correlated with neuronal count and positively correlated with levodopa-unresponsive features and constipation.

Conclusion/Significance: Analysis of the ENS by routine colonoscopy biopsies:

• Is a useful tool for pre-mortem neuropathological diagnosis of PD,

• And also provides insight into the progression of motor and non-motor symptoms.

Source: PLoS One, Sep 14, 2010;5(9): e12728. DOI:10.1371/journal.pone.0012728, by Lebouvier T, Neunlist M, de varannes SB, Coron E, Brouard A, N’guyen JM, Chaumette T, Tasselli M, Paillusson S, flamand M, Galmiche JP, Damier P, Derkinderen P. Inserm, Nantes; Universite de Nantes; CHU Nantes, France. [Email: thibaud.lebouvier@univ-nantes.fr]





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map