[Note: Dr. Ila R Singh, one of the retroviral researchers who in 2009 reported finding evidence of XMRV in malignant prostate tissue, proposes criteria for future XMRV & related virus testing studies to resolve the issue of “whether they are truly present in specimens taken from CFS patients.” To read the full text of this free access article, click HERE. And to read "What's Next for X?" - a discussion of the article by Wall Street Journal ME/CFS reporter Amy Dockser-Marcus - click HERE.]
XMRV or xenotropic murine leukemia virus-related retrovirus, a recently discovered retrovirus, has been linked to both prostate cancer and chronic fatigue syndrome (CFS).
Recently, the teams of Drs. Shyh-Ching Lo and Harvey Alter discovered the presence of sequences closely related to XMRV in the blood of 86.5% of patients with CFS .
These findings are important because since the initial discovery of XMRV in CFS, several studies have failed to find XMRV in specimens collected from CFS patients.
While the current study also did not find XMRV in CFS, Lo et al. did detect sequences that belong to polytropic mouse endogenous retroviruses (PMV), which share considerable similarity with XMRV.
Criteria for future studies that will help bring greater clarity to the issue of retroviral sequences in CFS are proposed below.
Source: Viruses, Nov 3, 2010. DOI:10.3390/v2112404. Singh IR. Department of Pathology, University of Utah, Salt Lake City, Utah, USA. [E-Mail: email@example.com]
1. “MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors.”