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Detecting Retroviral Sequences in Chronic Fatigue Syndrome – Source: Viruses, Nov 3, 2010

  [ 16 votes ]   [ 1 Comment ]
By Ila R Singh • • November 5, 2010

[Note: Dr. Ila R Singh, one of the retroviral researchers who in 2009 reported finding evidence of XMRV in malignant prostate tissue, proposes criteria for future XMRV & related virus testing studies to resolve the issue of “whether they are truly present in specimens taken from CFS patients.” To read the full text of this free access article, click HERE. And to read "What's Next for X?" - a discussion of the article by Wall Street Journal ME/CFS reporter Amy Dockser-Marcus - click HERE.]

XMRV or xenotropic murine leukemia virus-related retrovirus, a recently discovered retrovirus, has been linked to both prostate cancer and chronic fatigue syndrome (CFS).

Recently, the teams of Drs. Shyh-Ching Lo and Harvey Alter discovered the presence of sequences closely related to XMRV in the blood of 86.5% of patients with CFS [1].

These findings are important because since the initial discovery of XMRV in CFS, several studies have failed to find XMRV in specimens collected from CFS patients.

While the current study also did not find XMRV in CFS, Lo et al. did detect sequences that belong to polytropic mouse endogenous retroviruses (PMV), which share considerable similarity with XMRV.

Criteria for future studies that will help bring greater clarity to the issue of retroviral sequences in CFS are proposed below.

Source: Viruses, Nov 3, 2010. DOI:10.3390/v2112404. Singh IR. Department of Pathology, University of Utah, Salt Lake City, Utah, USA. [E-Mail:]

1. “MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors.”

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Article Comments Post a Comment

XMRV found by Lo & Alter study
Posted by: wingfingers
Nov 5, 2010
If I rightly recall, the original Lo & Alter paper was mentioned at the Zagreb conference and heralded as having found XMRV in a greater percentage of samples than even the original Lombardi paper. This was all over the Press. But it was stifled when the CDC were about to publish their totally-negative study (which proved only that they didn't know how to find XMRV), so Harvey Alter was told to withdraw his paper and modify it to bring it more into line with the CDC study. It appears that he removed all references to XMRV so that the much dumbed-down paper, published a couple of months later, only seemed to talk about the MLV sequences, while the CDC study was published almost immediately. We won't know the truth until and unless the original Lo & Alter paper is published. Meanwhile the whole world moves on and XMRV has been found in Norway and other places, and hopefully will soon be proven unequivocally to be causal in M.E.
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