ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Prevalence of depression in patients affected by subclinical hypothyroidism – Source: Panminerva Medicine, Dec 2010

  [ 15 votes ]   [ 2 Comments ]
By B Demartini, et al • • December 27, 2010

[Note: Subclinical hypothyroidism is a low-thyroid condition in which free thyroxine (T4) is normal and thyroid stimulating hormone (TSH) is between 5 and 25 mU/L. Though many doctors assume it doesn’t really have symptoms, others contend it does, and this study appears to indicate it is associated with depressive symptoms in the majority of cases, which generally are not eliminated by the thyroid hormone drug levothyroxine alone.]

Aim: The aim of this study was to:

• Estimate the prevalence of depressive symptoms in patients affected by subclinical hypothyroidism by means of Hamilton Rating Scale for Depression (HAM-D) and Montgomery-Asberg Depression Rating Scale (MADRS);

• To assess which depressive symptoms are prevalent in our population, with references to the factorialization of HAM-D by Cleary and Guy (1977);

• To verify whether levothyroxine replacement therapy alone can induce total remission of depressive symptoms. [Levothyroxine is a thyroid hormone used to treat hypothyroidism and goiter (enlarged thyroid gland).


The study enrolled 63 patients affected by subclinical hypothyroidism undergoing follow-up at the endocrinology service of San Paolo Hospital in Milan.

All patients underwent an evaluation by means of HAM-D and MADRS scales and serum TSH, free T4, free T3, TPO-Ab and Tg-Ab levels were measured.


We estimated a prevalence of depressive symptoms in our population of 63.5%.

Concerning the qualitative assessment of psychiatric disturbances in the population we considered, our results showed that the most frequent symptoms were part of four factors, according to the Cleary and Guy factorialization of HAM-D: these factors are representative of:

• Anxiety and somatisation (factor I),

• Cognitive impairment disturbances (factor III),

• Psychomotor retardation (factor V),

• And sleep disorders (factor VI).

Levothyroxine replacement therapy alone wasn't effective in inducing total remission of depressive symptoms.

Conclusion: This study suggests the importance of a psychiatric evaluation in patients affected by subclinical hypothyroidism.

Source: Panminerva Medicine, Dec 2010;52(4):277-82. PMID: 21183887 by Demartini B, Masu A, Scarone S, Pontiroli AE, Gambini O. Department of Psychiatry, San Paolo Hospital, University of Milan, Milan, Italy. [Email:]

Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

What about T3?
Posted by: uxordepp
Jan 14, 2011
Has there been a study like this done using T3 instead of T4? Some people apparently do better on T3 for hypoT as they do not convert the T4 properly. It seems to me that it's possible the reason the depression did not lift with T4 is because the thyroid hasn't actually been treated.
Reply Reply

depression & hypothyroid
Posted by: zeldaj
Jan 15, 2011
I have been diagnosed with hypothyroid and depression since my early twenties. I am now 76 and still suffering with depression although I am on 2 medications for that. I am currently taking Celexa 40mg and Gabapentin 900mg. I am taking 75mcq of Levothyroxine now. I do have a TSH drawn about every 6 weeks. I have taken extremely high doses of Levothyroxine and the TSH seems to change every time it is drawn. I do notice that my depression seems to be more pronounced when these changes occur with the TSH. Does anyone out there have any idea of what else I might do. Thank you
Reply Reply
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map