ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Restoring NAD+ could reduce DNA damage accumulation

What Benefits Can You Derive From Patchouli Oil?

Astaxanthin Is a Longevity Promoter

VIDEO: The Top Signs of Vitamin B1 Deficiency

 
Print Page
Email Article

Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication - Source: Neuropsychopharmacology, July 2008

  [ Not Yet Rated ]   [ Discuss This Article ]
By Chi-Hua Chen, Ed Bullmore, et al. • www.ProHealth.com • June 12, 2008


The amygdala plays a central role in various aspects of affect [emotional] processing and mood regulation by its rich anatomical connections to other limbic and cortical regions. It is plausible that depressive disorders, and response to antidepressant drugs, may reflect changes in the physiological coupling between the amygdala and other components of affect-related large-scale brain systems.

We explored this hypothesis by mapping the functional coupling of right and left amygdalae in functional magnetic resonance imaging data acquired from 19 patients with major depressive disorder and 19 healthy volunteers, each scanned twice (at baseline and 8 weeks later) during performance of an implicit facial affect processing task.

Between scanning sessions, the patients received treatment with an antidepressant drug, fluoxetine [brand name ProzacR] 20 mg/day.

We found that:

  • The amygdala was positively coupled bilaterally with medial temporal and ventral occipital regions,
  • And negatively coupled with the anterior cingulate cortex.
  • Antidepressant treatment was associated with significantly increased coupling between the amygdala and right frontal and cingulate cortex, striatum, and thalamus.
  • Treatment-related increases in functional coupling to frontal and other regions were greater for the left amygdala than for the right amygdala.
  • These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico-limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala.

    Source: Neuropsychopharmacology July 2008. 33 (8) 1909–1918; PMID: 17987064, by Chen CH, Suckling J, Ooi C, Fu CH, Williams SC, Walsh ND, Mitterschiffthaler MT, Pich EM, Bullmore E. Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. [E-mail: etb23@cam.ac.uk]





    Post a Comment

    Featured Products From the ProHealth Store
    Ultra ATP+, Double Strength Optimized Curcumin Longvida® Ultra EPA  - Fish Oil

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    NAD+ Ignite with Niagen

    Featured Products

    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid

    Natural Remedies

    Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
    Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
    Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
    Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery
    Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map