ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Antioxidant treatment could halt neurodegeneration in early Parkinson's

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

 
Print Page
Email Article

Metabolomic profiling to develop blood biomarkers for Parkinson’s disease – Source: Brain, Feb 2008

  [ Not Yet Rated ]   [ Discuss This Article ]
By Mikhail Bogdanov, M Flint Beal, et al. • www.ProHealth.com • April 7, 2008


The development of biomarkers for the diagnosis and monitoring of disease progression in Parkinson's disease (PD) is of great importance since diagnosis based on clinical parameters has a considerable error rate.

In this study, we utilized metabolomic profiling using high performance liquid chromatography coupled with electrochemical coulometric array detection (LCECA) to look for biomarkers in plasma useful for the diagnosis of PD. We examined 25 controls and 66 PD patients.

We also measured 8-hydroxy-2-deoxyguanosine (8-OHdG) levels as a marker of oxidative damage to DNA.

We initially examined the profiles of unmedicated PD subjects compared to controls to rule out confounding effects of symptomatic medications.

We found a complete separation of the two groups. We then determined the variables, which played the greatest role in separating the two groups and applied them to PD subjects taking dopaminergic medications.

Using these parameters, we achieved a complete separation of the PD patients from controls. 8-OHdG levels were significantly increased in PD patients, but overlapped controls.

Two other markers of oxidative damage were measured in our LCECA profiles.

  • Uric acid was significantly reduced,
  • While glutathione was significantly increased in PD patients.
  • These findings show that metabolomic profiling with LCECA coulometric array has great promise for developing biomarkers for both the diagnosis, as well as monitoring disease progression in PD.

    Source: Brain, 2008 131(2):389-396, PMID: 18222993, by Bogdanov M, Matson WR, Wang L, Matson T, Saunders-Pullman R, Bressman SS, Beal MF. Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital New York, NY: Bedford VA Medical Center, Bedford, MA; Department of Neurology, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY, USA. [E-mail: fbeal@med.cornell.edu]





    Post a Comment

    Featured Products From the ProHealth Store
    Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Ultra ATP+, Double Strength


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    Optimized Curcumin Longvida with Omega-3

    Featured Products

    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health

    Natural Remedies

    The Genetic Mutation That May Compromise Your Health - And What to Do About It The Genetic Mutation That May Compromise Your Health - And What to Do About It
    Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
    Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
    Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
    Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map