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Depressive Symptoms and Hypomagnesemia in Older Diabetic Subjects

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By L Guerrero-Romero, et al. • • June 4, 2007

Journal: Archives of Medical Research. 2007. Vol 38. In Press. [Available online May 16, 2007 ]

Authors and affilation: Barragan-Rodriguez L, Rodriguez-Moran M, Guerrero-Romero F. Medical Research Unit in Clinical Epidemiology, Mexican Social Security Institute; Research Group on Diabetes and Chronic Illnesses, Durango, Mexico. [E-mail: ]


Background: We undertook this study to assess the hypothesis that hypomagnesemia [low levels of magnesium in blood] is associated with depressive symptoms in older people with diabetes.

Methods: A total of 55 type 2 diabetic patients, aged 65 years or older, with depressive symptoms were compared with a control group of diabetic subjects without depressive symptoms in an age- and gender-matched case/control study.

A score =11 points in the Yesavage's scale was used for defining depressive symptoms, and hypomagnesemia was defined by serum magnesium levels <0.74 mmol/L. Well-known causes for depression as well as diseases and drugs that may cause depressive symptoms or hypomagnesemia were exclusion criteria.

Results: Serum magnesium levels were significantly lower among depressive than control diabetic subjects (0.74 ± 0.25 vs. 0.86 ± 0.29 mmol/L, p = 0.02). Twenty four (43.6%) and 7 (12.7%) individuals in the case and control group exhibited low serum magnesium levels (p = 0.0006). The adjusted logistic regression analysis showed an independent association between hypomagnesemia and depressive symptoms (OR 1.79; CI95% 1.1–6.9, p = 0.03).

Conclusions: Our results suggest that hypomagnesemia is independently associated with depressive symptoms in older people with diabetes.

Key Words: hypomagnesemia; depression; type 2 diabetes; aging

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