ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Genetic fibromyalgia subgroup with higher BMI & inflammation identified - UT San Antonio

  [ 27 votes ]   [ 3 Comments ] • July 24, 2011

A brain-derived neurotrophic factor polymorphism Val66Met identifies fibromyalgia syndrome subgroup with higher body mass index and C-reactive protein – Source: Rheumatology International, Jul 21, 2011

By Yangming Xiao, Jon Russell, Ya-Guang Liu

[Note (supplied by Co-Cure Listserv poster Kelly): "Subgrouping patients is important not only in ME and CFS, but other diseases and conditions as well. Subgrouping can be used to better target therapies as well as determining possible etiological differences. Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF gene. BDNF acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses.

"In the brain, it is active in the hippocampus, cortex, and basal forebrain - areas vital to learning, memory, and higher thinking. BDNF itself is important for long-term memory. BDNF was the second neurotrophic factor to be characterized after nerve growth factor (NGF). Despite its name, BDNF is actually found in a range of tissue and cell types, not just in the brain."]


A common single nucleotide polymorphism (SNP) in the gene of brain-derived neurotrophic factor (BDNF) results from a substitution at position 66 from valine (Val) to methionine (Met) and may predispose to human neuropsychiatric disorders. We proposed to determine whether these BDNF gene SNPs were associated with fibromyalgia syndrome (FMS) and/or any of its typical phenotypes.

Patients with FMS (N = 95) and healthy normal controls (HNC, N = 58) were studied. Serum high-sensitivity C-reactive protein (hsCRP) levels were measured using an enzyme-linked immunosorbent assay (ELISA). [C-reactive protein levels in the blood rise in response to and are a marker of systemic inflammation.]

The BDNF SNPs were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

The BDNF SNP distribution was 65 (68%) Val/Val, 28 (30%) Val/Met, and 2 (2%) Met/Met for FMS and 40 (69%), 17(29%), and 1 (2%) for HNC, respectively. The serum high-sensitivity C-reactive protein (hsCRP) and body mass index (BMI) in FMS were higher than in healthy normal controls.

The FMS with BDNF Val66Val had significantly higher mean BMI (P = 0.0001) and hsCRP (P = 0.02) than did FMS carrying the Val66Met genotype.

This pattern was not found in healthy normal controls. Phenotypic measures of subjective pain, pain threshold, depression, or insomnia did not relate to either of the BDNF SNPs in FMS.

The relative distribution BDNF SNPs did not differ between FMS and healthy normal controls. The BDNF Val66Met polymorphism is not selective for FMS.

The BDNF Val66Val SNP identifies a subgroup of FMS with elevated hsCRP and higher BMI. This is the first study to associate a BDNF polymorphism with a FMS subgroup phenotype. [A phenotype is a gene-associated type with distinctive characteristic(s).]

Source: Rheumatology International, Jul 21, 2011. PMID:21773883, by Xiao Y, Russell IJ, Liu YG. Department of Medicine\Clinical Immunology, University of Texas Health Science Center at San Antonio, Texas, USA. [Email:]

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

Can I get a translation?
Posted by: Happy2day
Jul 24, 2011
Fibrofog? Ignorant? Blonde? I read this stuff and feel dumb. Could someone would be so kind as to explain the significance of this study?
Reply Reply

val66met snp
Posted by: IanH
Jul 26, 2011
The gene error (variant) where methionine is substituted for valine in the protein called BDNF occurs because of an error (variant) in the gene responsible for making the protein (Probably in the DNA but may be only in the RNA which actually makes the protein.) This possibly means it is inherited. The incidence in this study for the val/met variant was around 30% of people with FMS + high BMI ie it accounts for 30% of fms in overweight FMS sufferers. It does not say that FMS is caused by this polymorphism but that it is probably a risk factor and may determine some of the symptoms or symptom severity and possibly explains some of the memory problems. People with ME with this polymorphism will probably therefore have widespread pain. A next step would be to study people with ME who report widespread pain to see if they have a similar incidence of this variant. Treatment? Well we haven't been too successful at treating these type of genetic variants but new therapies are coming along.
Reply Reply

thanks for the explanation
Posted by: Ly45nn
Jul 27, 2011
Great explanation, now if we could get treatment!
Reply Reply

Post a Comment

Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Breaking Through the Mental Fog Breaking Through the Mental Fog
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map