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Evidence-based psychopharmacology 1. Appraising a single therapeutic trial: what is the evidence for treating early Alzheimer's disease with donepezil?

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By Warner JP • www.ProHealth.com • November 1, 1999


Expertise in setting appropriate, answerable clinical questions, undertaking an accurate search of databases, and appraising the evidence found are all key elements to practising evidence-based medicine. Using the published evidence of the utility of donepezil in Alzheimer's disease as an example, I have attempted to illustrate the process of critical appraisal of a therapeutic intervention. The study appraised was well conducted and the results indicate that donepezil may benefit some patients with Alzheimer's disease.

Source: J Psychopharmacol 1999;13(3):308-12
PMID: 10512093, UI: 99440644

(Imperial College of Science, Technology and Medicine, St Charles Hospital, London, UK. j.warner@ic.ac.uk )




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