Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Big step towards cure for HIV and other lifelong viral infections

SURVEY RESULTS: Attitudes About Fatigue

Superfood Trio: Ginger, Turmeric, and Carrots?

How Omega-3 Fights Depression

Rejuvenate Your Skin Naturally With Sea Buckthorn Oil

A Smile

Can Drinking More Water Help You Lose Weight?

Resveratrol’s Link to Slowing Alzheimer’s

Tropical Turmeric Carrot Juice & Smoothie

Most Everyone Can Use More Vitamin D

 
Print Page
Email Article

Is overall genome instability cause of ME/CFS? $133K study may help answer that

  [ 17 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 2, 2012


A national foundation has sought out a Wayne State University researcher in an effort to discover whether overall genome instability rather than a specific molecular mechanism may cause chronic fatigue and immune dysfunction syndrome (CFIDS).

Henry Heng, PhD, associate professor at the Center for Molecular Medicine and Genetics & department of pathology at Wayne State University's School of Medicine, recently received a $133,000 grant from the National CFIDS Foundation in collaboration with the Nancy Taylor Foundation for Chronic Diseases.

Dr. Heng is to assess disease damage in patients with CFIDS, which also is known as chronic fatigue syndrome/myalgic encephalopathy (CFS/ME).

He will use an advanced type of genomic testing to look for chromosomal aberrations or genomic instability in CFS/ ME patients.

Dr. Heng believes scientists who have looked to single genes / mutations as the cause of diseases with complex sets of symptoms need to broaden their search to genomes.

That belief is based on his work of 10 years on cancer, which has demonstrated that cancer progresses primarily through random chromosomal changes.

Though that concept seemed hard for some to accept five to seven years ago, says Dr. Heng, the scientific community has started to come around.

In 2007 producers at the Discovery Channel sought to establish the existence of Gulf War syndrome and asked Dr. Heng to test samples of soldiers' blood: Those samples were found to contain damaged chromosomes.

"To our surprise,” said Dr. Heng, “we found that all of the GWI patients tested showed extremely high levels of chromosomal abnormality that were as high or higher than some cancer patients." The researchers proposed that “under the extreme environment of war, some individuals’ genomes will become increasingly unstable, and war-induced genetic instability will lead to diverse disease traits that can be characterized as GWI.”

An official at the National CFIDS Foundation saw the program and agreed.

Reasoning that CFIDS, like cancer, is a complex disease with a wide range of symptoms and varying degrees of severity, the official asked Dr. Heng to investigate it.

Dr. Heng's project, "Linking Genomic Instability to Chronic Fatigue and Immune Dysfunction Syndrome," will use spectral karyotyping, or SKY analysis, to evaluate whether the process may reveal instability similar to Gulf War syndrome in CFIDS/ME.

Essentially that process would demonstrate whether CFIDS/ME has a common physical basis.

His team will culture patients' blood and perform SKY analysis, which paints each chromosome with a unique color to identify random genome aberrations that might be linked to symptoms.

"For a long time people have studied gene mutation-based genetic diseases, believing if you found the right mutation, you could cure the disease," says Dr. Heng. "But this is misleading thinking, because most common complex diseases are not caused by one or two genes, but a whole package of genome alterations.

"However, we have discovered that chromosomal change has a more profound effect in many diseases. Our group has shown that random chromosomal changes matter.

"We really need to know the problem we face rather than engage in wishful thinking."

Source: Based on Wayne State University news releases, Mar 30, 2012, and  Apr 7, 2011




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map