Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

12 Celebrities with Lyme Disease

Single Low-magnitude Electric Pulse Successfully Fights Inflammation

Why Is Spicy Food Good for You?

Parasites and Worms As Major Complicating Co-Factors In Lyme Disease Recovery

How Essential Oils Can Help Improve Your Life

Omega-3 fatty acids may help improve treatment, quality of life in cancer patients

Ask the Doctor- Is it possible to be fully healed from or cured of Lyme Disease?

Clinically Studied Joint Relief Product for FM & ME/CFS

Anti-histamine drug Claritin can kill Borrelia by interfering with manganese utilization

 
Print Page
Email Article

Exercise Reduces Fibromyalgia Fatigue

  [ 3 votes ]   [ 1 Comment ]
www.ProHealth.com • March 3, 2013


Editor's Note: The goal of this study was to evaluate the effects of exercise on fibromyalgia fatigue in patients who were lean, overweight and obese.  The researchers also investigated the influence of adipokines (cytokines produced by adipose tissue) and growth factors on fatigue levels. 

They found that exercise did reduce fatigue levels, however, they noted that this reduction in fatigue occurred earlier for the lean patients.  In addition, they identified IGF-1 (insulin-like growth factor – a hormone similar in molecular structure to insulin) and resistin (a cytokine that causes resistance of peripheral tissues to insulin) as being involved in the beneficial effects exercise had on fatigue.

Following is the abstract for this study.


Article:

Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?
– Source: Arthritis Research and Therapy, February 27, 2013

By J.L. Bjersing, et al.

Abstract:

INTRODUCTION: Severe fatigue is a major health problem in fibromyalgia (FM). Obesity is common in FM, but the influence of adipokines and growth factors is not clear. The aim was to examine effects of exercise on fatigue, in lean, overweight and obese FM patients.

METHODS: In a longitudinal study, 48 FM patients (median 52 years) exercised for 15 weeks. Nine patients were lean (body mass index, BMI 18.5-24.9), 26 overweight (BMI 25-29.9) and 13 obese. Fatigue was rated on a 0-100 mm scale (fibromyalgia impact questionnaire [FIQ] fatigue) and multidimensional fatigue inventory (MFI-20) general fatigue (MFIGF). Higher levels in FIQ fatigue and MFIGF indicate greater degree of fatigue. Free and total IGF-1, neuropeptides, adipokines were determined in serum and cerebrospinal fluid (CSF).

RESULTS:

  • Baseline FIQ fatigue correlated negatively with serum leptin (r=-0.345; p=0.016) and nerve growth factor (NGF; r=-0.412; p=0.037).

  • In lean patients, baseline MFIGF associated negatively with serum resistin (r=-0.694; p=0.038).

  • FIQ Fatigue associated negatively with CSF resistin (r=-0.365; p=0.073).

  • Similarly, FIQ fatigue (r=-0.444; p=0.026) and MFIGF correlated negatively with CSF adiponectin (r=-0.508; p=0.01).

  • In lean patients, FIQ fatigue (p=0.046) decreased after 15 weeks.

  • After 30 weeks, MFIGF decreased significantly in lean (MFIGF: p=0.017), overweight (MFIGF: p=0.001), and obese patients (MFIGF: p=0.016).

  • After 15 weeks, total IGF-1 increased in lean (p=0.043) patients.

  • [increment]Total IGF-1 differed significantly between lean and obese patients (p=0.010).

  • [increment]Total IGF-1 related negatively with [increment]MFIGF after 15 weeks (r=-0.329; p=0.050).

  • After 30 weeks, [increment]FIQ fatigue negatively correlated with [increment]NGF (r=-0.463; p=0.034) and positively with [increment]neuropeptide Y (NPY) (r=0.469; p=0.032).

  • Resistin increased after 30 weeks (p=0.034).

  • [increment]MFIGF correlated negatively with [increment]resistin (r=-0.346; p=0.031), being strongest in obese patients (r=-0.815; p=0.007).

  • In obese patients, [increment]FIQ fatigue after 30 weeks correlated negatively with [increment]Free IGF-1 (r=-0.711; p=0.032).

CONCLUSIONS: Exercise reduced fatigue in all FM patients, this effect was achieved earlier in lean patients. Baseline levels of resistin in both serum and CSF associated negatively with fatigue. Resistin was increased after the exercise period which correlated with decreased fatigue. Changes in IGF-1 indicate similar long-term effects in obese patients. This study shows reduced fatigue after moderate exercise in FM and indicates the involvement of IGF-1 and resistin in these beneficial effects.


Source: Arthritis Research and Therapy, February 27, 2013. By J.L. Bjersing, M. Erlandsson, M.I. Bokarewa, K. Mannerkorpi.




Please Discuss This Article:   Post a Comment 

exercise
Posted by: roge
Mar 4, 2013
right on schedule - yet another study promoting exercise and saying it helps FM - sigh
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
"It's Not Easy Being Green" - But It Is Healthy
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing