Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Researchers find herpes strain in the nervous system

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Nature Heals

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

 
Print Page
Email Article

CoQ10 Reduces Inflammation and Enhances Antioxidant Activity in Patients With Coronary Artery Disease

  [ 18 votes ]   [ 1 Comment ]
By Erica Verrillo • www.ProHealth.com • November 12, 2013


Research Summary: Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial.

At the May 2013 Heart Failure Congress a randomized double blind trial was presented showing that CoQ10 caused a 50% decrease in mortality from all cardiac events. As this was the first treatment in over a decade to improve heart failure mortality, the news made headlines in the scientific community. Other CoQ10 studies were bound to follow. 

The most recent study to focus on the benefits of CoQ10 for heart health comes from Taiwan, where a group of researchers in Taichung studied the effects of CoQ10 supplementation on patients receiving statins (cholesterol-reducing drugs). Statins have been shown to reduce the biosynthesis of CoQ10, a powerful antioxidant found in nearly all cells of the human body. (CoQ10 works to produce energy in mitochondria, and is the only antioxidant that humans can synthesize.) The researchers investigated the effects that supplementation with CoQ10 might have on patients during statin therapy, particularly its effect on inflammatory markers which are directly correlated with coronary artery disease. 

A cohort of 54 patients with 50% stenosis of at least one coronary artery was divided into two groups. Twenty-seven patients were randomly chosen to receive 300mg of CoQ10 daily for twelve weeks, while twenty-four received placebo. Concentrations of coenzyme Q10 and vitamin E were measured in the two groups, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase. Inflammatory markers - C reactive protein (CRP), tumor necrosis factor-alpha and interleukin-6 - were measured in the 42 subjects who completed the study.

At the end of twelve weeks, the researchers found that plasma levels of CoQ10 as well as antioxidant enzyme activity were significantly higher after CoQ10 supplementation. In addition, the subjects in the CoQ10 group had significantly higher levels of vitamin E than the placebo group. Levels of the inflammatory markers tumor necrosis factor-alpha and interleukin-6 dropped in the CoQ10 group, indicating a decrease in oxidative stress.

The authors concluded that “Coenzyme Q10 supplementation at 300 mg/d significantly enhances antioxidant enzymes activities and lowers inflammation in patients who have CAD [coronary artery disease] during statins therapy.” They also found that regarding the safety of COQ10 “there were no clinically significant changes in the subjects’ vital signs, serum chemical values, or hematological values, and there were no serious adverse events, no complaints of myalgia or muscle weakness, and no withdrawals due to adverse events. Thus, coenzyme Q10 at a dose of 300 mg/d is safe for co-administration with statins therapy.”

Citation: Bor-Jen Lee, Yu-Fen Tseng, Chi-Hua Yen and Ping-Ting Lin. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutrition Journal 2013, 12:142, 6 November 2013  doi:10.1186/1475-2891-12-142 



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

One thing not mentioned
Posted by: moose_29
Nov 17, 2013
Supplementing CoQ10 will hopefully reduce the risk of increased mortality from cancer and degenerative brain disease associated with statin usage. Might be a good idea to supplement Vitamin D as well as it's production (like that of CoQ10) is substantially decreased in those taking statins.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Live Without Anxiety or Stress Live Without Anxiety or Stress
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map