ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

 
Print Page
Email Article

CoQ10 Reduces Inflammation and Enhances Antioxidant Activity in Patients With Coronary Artery Disease

  [ 18 votes ]   [ 1 Comment ]
By Erica Verrillo • www.ProHealth.com • November 12, 2013


Research Summary: Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial.

At the May 2013 Heart Failure Congress a randomized double blind trial was presented showing that CoQ10 caused a 50% decrease in mortality from all cardiac events. As this was the first treatment in over a decade to improve heart failure mortality, the news made headlines in the scientific community. Other CoQ10 studies were bound to follow. 

The most recent study to focus on the benefits of CoQ10 for heart health comes from Taiwan, where a group of researchers in Taichung studied the effects of CoQ10 supplementation on patients receiving statins (cholesterol-reducing drugs). Statins have been shown to reduce the biosynthesis of CoQ10, a powerful antioxidant found in nearly all cells of the human body. (CoQ10 works to produce energy in mitochondria, and is the only antioxidant that humans can synthesize.) The researchers investigated the effects that supplementation with CoQ10 might have on patients during statin therapy, particularly its effect on inflammatory markers which are directly correlated with coronary artery disease. 

A cohort of 54 patients with 50% stenosis of at least one coronary artery was divided into two groups. Twenty-seven patients were randomly chosen to receive 300mg of CoQ10 daily for twelve weeks, while twenty-four received placebo. Concentrations of coenzyme Q10 and vitamin E were measured in the two groups, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase. Inflammatory markers - C reactive protein (CRP), tumor necrosis factor-alpha and interleukin-6 - were measured in the 42 subjects who completed the study.

At the end of twelve weeks, the researchers found that plasma levels of CoQ10 as well as antioxidant enzyme activity were significantly higher after CoQ10 supplementation. In addition, the subjects in the CoQ10 group had significantly higher levels of vitamin E than the placebo group. Levels of the inflammatory markers tumor necrosis factor-alpha and interleukin-6 dropped in the CoQ10 group, indicating a decrease in oxidative stress.

The authors concluded that “Coenzyme Q10 supplementation at 300 mg/d significantly enhances antioxidant enzymes activities and lowers inflammation in patients who have CAD [coronary artery disease] during statins therapy.” They also found that regarding the safety of COQ10 “there were no clinically significant changes in the subjects’ vital signs, serum chemical values, or hematological values, and there were no serious adverse events, no complaints of myalgia or muscle weakness, and no withdrawals due to adverse events. Thus, coenzyme Q10 at a dose of 300 mg/d is safe for co-administration with statins therapy.”

Citation: Bor-Jen Lee, Yu-Fen Tseng, Chi-Hua Yen and Ping-Ting Lin. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutrition Journal 2013, 12:142, 6 November 2013  doi:10.1186/1475-2891-12-142 


Please Discuss This Article:   Post a Comment 

One thing not mentioned
Posted by: moose_29
Nov 17, 2013
Supplementing CoQ10 will hopefully reduce the risk of increased mortality from cancer and degenerative brain disease associated with statin usage. Might be a good idea to supplement Vitamin D as well as it's production (like that of CoQ10) is substantially decreased in those taking statins.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing