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www.ProHealth.com • March 14, 2003


In a study of mice genetically engineered to have rheumatoid arthritis, French researchers have determined that the antioxidant vitamin E has the potential to prevent the destruction of cartilage tissue and inhibit pro-inflammatory proteins. In a study published in the journal Arthritis and Rheumatism, researchers found that although vitamin E failed to alleviate the symptoms of rheumatoid arthritis, it did have an effect on the loss of cartilage and amounts inflammatory substances caused by the autoimmune disease. The vitamin treated mice continued to show symptoms of the disease, however the progressive destruction of joint cartilage was significantly less than the control group.

The study also showed a reduction in the inflammatory protein called interleukin 1-beta, a substance produced by the immune system and involved in joint destruction. Despite the benefits of vitamin E, the precise reason as to how it prevented joint destruction in the mice is unclear. The researchers concluded further testing needs to be done to determine what these processes are, and their potential treatment for rheumatoid arthritis in humans.

(Source: Arthritis and Rheumatism Vol. 46, (2), 2002)



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