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Autoimmune markers and autoimmune disorders in patients with postural tachycardia syndrome (POTS)

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By S Blitshteyn • www.ProHealth.com • June 20, 2015


By S Blitshteyn

Abstract

Objective: In recent years, there have been a number of studies suggesting that POTS may have an autoimmune etiology. This study examined whether the prevalence of antinuclear antibodies (ANA), other markers of autoimmunity and co-morbid autoimmune disorders is higher in patients with POTS than in the general population.
 
Methods and results: Medical records of 100 consecutive patients with POTS evaluated at our clinic were reviewed. In this cohort (90% females, mean age 32, range 13–54 years), 25% had positive ANA, 7% had at least one positive aPL antibody and 31% had markers of autoimmunity. When compared to the general population, patients with POTS had a higher prevalence of ANA (25% vs. 16%, OR 1.8, CI 1.1–2.8, p?
Conclusion: Patients with POTS have a higher prevalence of autoimmune markers and co-morbid autoimmune disorders than the general population. One in four patients have positive ANA, almost one in three have some type of autoimmune marker, one in five have a co-morbid autoimmune disorder, and one in nine have Hashimoto’s thyroiditis.
 
Source: S Blitshteyn. Autoimmune markers and autoimmune disorders in patients with postural tachycardia syndrome (POTS). Lupus June 1, 2015




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