ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

Cancer-Fighting Drug May Work in Prevention and Treatment

  [ 13 votes ]   [ Discuss This Article ]
By xx • www.ProHealth.com • January 7, 2002





PHILADELPHIA — The ABCs of fighting cancer these days include two big words that describe exciting basic concepts. One is anti-angiogenesis, a strategy to stop or prevent the growth of blood vessels needed to nourish a tumor and allow it to spread. Another approach is chemoprevention—using medication to halt, delay or reverse the development of cancer.

According to new prevention research by Fox Chase Cancer Center cell biologist Margie Clapper, Ph.D., of Harleysville, Pa., and colleagues at Cephalon Inc. in West Chester, Pa., the drug Oltipraz holds the potential to achieve both goals. A report on the ongoing studies appears in the January 2002 issue of Clinical Cancer Research. Co-authors include Dr. Clapper and Bruce Ruggeri, Ph.D., of Cephalon’s Division of Oncology.

Clapper has been studying Oltipraz for more than a decade, concentrating on its ability to raise blood levels of protective “detoxification” enzymes that help ward off cancer. These enzymes resemble antioxidant compounds in broccoli, cabbage and similar vegetables.

In early clinical studies, Clapper worked with Fox Chase medical oncologist Christine Szarka, M.D., to see how well Oltipraz increased protective enzymes among people at high risk of colon cancer. For comparison, some trial participants took dried broccoli tablets instead of the drug. Oltipraz surpassed the dietary approach by a significant measure with few or no side effects. A later study used Oltipraz for people at risk of lung cancer.

Most recently, with support from the Cancer Research Foundation of America, Clapper has focused on individuals with ulcerative colitis, which increases the risk of colon or rectal cancer by 10 times. In studies with laboratory mice, Oltipraz has proved to inhibit colitis-associated colon cancer. This research will form a basis for designing the first trial of a preventive treatment for people with this disease.

The drug’s ability to boost protective enzymes and decrease DNA damage from cancer-causing agents was thought to explain its success in halting the development and spread of a variety of tumors in mice and rats. But in evaluating this laboratory work, Clapper says, “we’ve seen tumor growth halted without an elevation of detoxification enzymes.”

That observation led the researchers to look at Oltipraz’ anti-angiogenesis ability. They started with studies using microarray technology, which can simultaneously analyze the activity of thousands of genes. This revealed that Oltipraz may have the ability to affect blood vessel growth.

A series of experiments in laboratory rodents then demonstrated that Oltipraz is an anti-angiogenic agent comparable in potency to two drugs currently being tested in clinical trials. One is SU 5416, now being tested at Fox Chase for patients with melanoma or sarcoma.

“Based on our work with animal tumor models, Oltipraz may not only be a cancer prevention agent but may also be effective in treating patients with advanced stage cancers and metastases,” Clapper explains. “We’re still doing pre-clinical testing,” she emphasized.

Cephalon is screening the drug in mice with several kinds of tumors to gain additional data about the most appropriate cancer sites for a future treatment trial of Oltipraz in humans. In addition to support from Cephalon and the Cancer Research Foundation of America, a National Institutes of Health grant and Commonwealth of Pennsylvania appropriation are helping fund research on Oltipraz’ anti-angiogenic activity.

Although still in clinical development for its broad-based chemoprevention activity, Oltipraz could turn out to be a doubly potent weapon against cancer—either helping prevent it in high-risk people or shrinking cancerous tumors by depriving them of their blood supply.

This wouldn’t be the first time Oltipraz showed promise beyond its established use, however. It was first approved as an anti-schistosomal treatment, to eliminate parasites known as blood flukes. In the same way, research aimed specifically at preventing cancer may serendipitously yield new approaches to cancer treatment as well.

Fox Chase Cancer Center, one of the nation’s first comprehensive cancer centers designated by the National Cancer Institute in 1974, conducts basic and clinical research; programs of prevention, detection and treatment of cancer; and community outreach. For more information about Fox Chase activities, visit the Center’s web site at http://www.fccc.edu or call 1-888-FOX CHASE.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map