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Lack of detectable variation at Borrelia burgdorferi vlsE locus in ticks.

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By Nosbisch LK, de Silva AM • www.ProHealth.com • January 1, 2007


Abstract

VlsE is a surface exposed lipoprotein of the Lyme disease spirochete, Borrelia burgdorferi. Spirochetes are able to generate many antigenic variants of VlsE by DNA recombination at the vlsE locus. Novel VlsE antigenic variants are readily observed in mice infected with B. burgdorferi. We followed a clonal population of spirochetes through a tick transmission cycle and report that unlike in vertebrates, the vlsE locus is stable in ticks.

J Med Entomol. 2007 Jan;44(1):168-70. Research Support, N.I.H., Extramural





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