ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis adds evidence to association between omega-3 supplementation and lower heart rate

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Mediterranean diet associated with lower risk of aggressive prostate cancer

 
Print Page
Email Article

Abstract: Genomics of osteoarthritis

  [ 46 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 18, 2003


Curr Opin Rheumatol. 2003 Sep;15(5):634-40.

Aigner T, Dudhia J.

Cartilage Research Group, Department of Pathology, University of Erlangen-Nurnberg, Erlangen Germany. thomas.aigner@patho.imed.uni-erlangen.de

PURPOSE OF REVIEW: This review addresses the progress in three major fields of "genomics of osteoarthritis" over the past year: genetic alterations thought to be important for the initiation and progression of osteoarthritis, differential gene expression analysis, and functional genomics of osteoarthritis.

RECENT FINDINGS: Distinct genetic risk factors may predispose different joint sites to osteoarthritis, and although clear loci for susceptibility genes for common osteoarthritis have yet to emerge from the epidemiological studies, new approaches are narrowing down known loci.

The search for specific genes using cDNA array technology has further demonstrated its potential in arthritis research as a powerful tool that could further provide biological insights into disease mechanisms, osteoarthritis polymorphic subtypes, the molecular validation of animal models, and the monitoring of drug activity on gene expression levels. Gene expression analysis has further characterized the striking shift in the gene expression pattern during "dedifferentiation" of chondrocytes in vitro as well as added depth to the phenotype of differentiated versus undifferentiated mesenchymal stem cells. Several new molecules potentially relevant to the disease process were identified, among them beta2-microglobulin (B2M), clusterin, and chitinase-like molecule 2.

SUMMARY: Functional genomic approaches will in the future allow to complement traditional biochemistry and molecular biology. Although there are limitations to cDNA array technology, "molecular portraits" of osteoarthritic chondrocytes in vivo and in vitro can be produced to analyze whole or large biologic systems rather than just single aspects of it. This will stimulate the testing of new markers, which are needed for the diagnosis and monitoring of osteoarthritis.

PMID: 12960493 [PubMed - in process]




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Vitamin D3 Extreme™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium

Natural Remedies

When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Break Free From Fibromyalgia Break Free From Fibromyalgia
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map