ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Estrogen-Like Molecules

  [ Not Yet Rated ]   [ Discuss This Article ]
By Report by the AD Educ & Referral Ctr • • March 1, 1997

In addition to pursuing today's strongest prospects in their search for effective AD therapies, NIA's Drug Discovery Groups open new lines of inquiry and reexamine areas of research that others may assume are closed. Dr. James Simpkins, who directs a Drug Discovery Group at the University of Florida in Gainesville, says that the progress of his own career in AD research proves the value of exploring a range of theories--unpopular as well as popular. "My colleagues and I first became interested in estrogen in the mid-1980's. At that time, most researchers dismissed the idea that it had any role in AD. Today, estrogen has taken center stage."

Currently, Dr. Simpkins' team is working to transform the estrogen molecule into a safe and beneficial compound for people who have or are at risk for AD. Describing the group's efforts, he says, "Based on the substantial evidence that estrogen protects neurons, we set out to build models that explain how it works." Studying animals and tissue cultures, this team eventually linked estrogen's benefits to its anti-oxidant function. "With estrogen, we drastically reduced oxidation damage in tissue cultures and correlated that activity with less cell death," notes Dr. Simpkins. In addition, the group found that estrogen's neuron-protecting activities are not related to its "feminizing" properties, and that activating estrogen receptors is unnecessary to protect neurons. Receptors are proteins that recognize and bind to chemical messengers, such as neurotransmitters.

Building on these discoveries, Dr. Simpkins' team made a series of minor changes at various places in the structure of the estrogen molecule. The team sought to produce new substances that kept estrogen's anti-oxidant potential, but lost its feminizing qualities. They developed 10 molecules that may help protect neurons but do not act like sex hormones. Dr. Simpkins speculates that hundreds of similar, estrogen-like molecules may be found.

The University of Florida team also found that normal levels of estrogen help protect neurons. This finding suggests that estrogen-like therapies may be administered effectively at relatively low doses over many years. Dr. Simpkins notes that estrogen may help with other diseases of the central nervous system, including Parkinson's disease, and strokes.

In an agreement with a pharmaceutical company, Dr. Simpkins and his colleagues will further develop 3 of the 10 modified estrogen molecules prepared at the University of Florida. Paving the way for clinical trials, the drug company will test these substances in mice genetically engineered to produce abnormally high levels of APP. The company seeks to find out if the substances protect brain cells from the possibly toxic effects of amyloid.

Source: Connections Magazine [Volume 6(1), Spring 1997]


Aisen, P.S.; Davis, K.L. Inflammatory Mechanisms in Alzheimer's Disease: Implications for Therapy. American Journal of Psychiatry. 151(8): 1105-1113. August 1994.
Paganini-Hill, A.; Henderson, V.W. Estrogen Deficiency and Risk of Alzheimer's Disease in Women. American Journal of Epidemiology. 140(3): 256-261. August 1, 1994.
Rogers, J.; et al. Clinical Trial of Indomethacin in Alzheimer's Disease. Neurology. 43(8): 1609-1611. August 1993.
Simpkins, J.W.; Singh, M.; Bishop, J. The Potential Role for Estrogen Replacement Therapy in the Treatment of the Cognitive Decline and Neurodegeneration Associated With Alzheimer's Disease. Neurobiology of Aging. 15(Suppl 2): S195-S197. 1994.
Stewart, W.F.; et al. Risk of Alzheimer's Disease and Duration of NSAID Use. Neurology. 48(3): 626-632. March 1997.
Tang, M.X.; et al. Effect of Oestrogen During Menopause on Risk and Age at Onset of Alzheimer's Disease. The Lancet. 348(9025): 429-432. August 17, 1996.
Thal, L. Future Directions for Research in Alzheimer's Disease. Neurobiology of Aging. 15(Suppl 2): S71-S72. 1994.
Whitehouse, P.J. Cholinergic Therapy in Dementia. ACTA Neurology Scandinavia. Suppl 149: 42-45. 1993.

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map