ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

A Little Zinc Goes a Long Way

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Researchers Identify a Key

  [ 5 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 4, 2002



New York, N.Y.— (1/27/02)- When the body is exposed to a foreign substance, such as a virus or bacteria, the immune system responds in an elaborate process by making cells and agents that fight off the invaders.

But sometimes physicians want to be able to turn off the immune response, such as during bone marrow or organ transplants to prevent the host from rejecting the donor tissue. On the other hand, doctors would like to boost the immune response against malignant cells and HIV-infected cells to help fight cancer and AIDS.

Now scientists at Columbia University College of Physicians & Surgeons and elsewhere report they have identified a key pair of molecules, called ILT3 and ILT4, that could help clinicians precisely modulate the immune response to help treat a variety of diseases. The molecules are the first to be characterized on antigen presenting immune cells, called dendritic cells, to function as a brake for the immune response. Antigens are molecules, such as proteins from viruses or even from the body’s own tissue, that can elicit an immune response.

The findings are being reported Jan. 27 in the online version of Nature Immunology and in the February issue of the publication.

Led by Dr. Nicole Suciu-Foca, professor of clinical pathology, the researchers provide evidence for how increasing the amount of ILT3 and ILT4 on dendritic cells could create tolerance to foreign tissues, such as donor tissue or bone marrow. Their results also suggest that somehow decreasing the amount of ILT3 and ILT4 on these cells might allow the body to better fight AIDS and cancer cells.

ILT3 and ILT4 on dendritic cells function as a brake for the immune system, shutting off the immune response and then creating a state of tolerance to antigens, which can be foreign or derived from the body itself, explains Dr. Suciu-Foca. To shut down the immune response, the body presses its “foot” harder on the brake pedal to boost ILT3 and ILT4 activity in the dendritic cells. To enhance the immune response, the body lowers the ILT3 and ILT4 activity.

In the study, the investigators showed how other cells of the immune system, the T-suppressor cells, are responsible for slowing down the activity of the dendritic cells. Dendritic cells present to T cells, including T suppressor cells, the specific antigen against which the immune response had been initiated.

In the study, the researchers showed in cell culture how increasing the activity of ILT3 and ILT4 on dendritic cells could make the immune system tolerant to antigens. They also analyzed the blood of heart transplant recipients and showed that those who did not reject donor hearts had T-suppressor cells that induced the activity of ILT3 and ILT4 in donor dendritic cells. The results show that the heart recipients without rejection had T-suppressor cells that had been primed to suppress a response to foreign hearts.

The findings of the study also have implications for type I diabetes and other autoimmune diseases, Dr. Suciu-Foca says. In autoimmune disease, the immune system attacks normal body tissue rather than being tolerant of it. Enhancing activity of ILT3 and ILT4 in dendritic cells, which present the target antigen in such patients, might help affected patients suppress the immune response against their own tissues.

Dr. Suciu-Foca and her colleagues are now investigating the possible use of ILT3 and ILT4 to treat patients with AIDS, cancer, or transplants.

The research was supported by grants from the National Institutes of Health and the Interuniversity Organ Transplantation Consortium in Rome, Italy.

Contact: Annie Bayne
212-305-3900
as862@columbia.edu



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map