ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Natural Remedies for the Prevention of Dry Eyes

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

CoQ10's Potential Capabilities for Your Health

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

Testosterone replacement therapy associated with improved urinary, sexual function

8 Chia Seed Recipes

 
Print Page
Email Article

Researchers Identify a Key

  [ 5 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 4, 2002



New York, N.Y.— (1/27/02)- When the body is exposed to a foreign substance, such as a virus or bacteria, the immune system responds in an elaborate process by making cells and agents that fight off the invaders.

But sometimes physicians want to be able to turn off the immune response, such as during bone marrow or organ transplants to prevent the host from rejecting the donor tissue. On the other hand, doctors would like to boost the immune response against malignant cells and HIV-infected cells to help fight cancer and AIDS.

Now scientists at Columbia University College of Physicians & Surgeons and elsewhere report they have identified a key pair of molecules, called ILT3 and ILT4, that could help clinicians precisely modulate the immune response to help treat a variety of diseases. The molecules are the first to be characterized on antigen presenting immune cells, called dendritic cells, to function as a brake for the immune response. Antigens are molecules, such as proteins from viruses or even from the body’s own tissue, that can elicit an immune response.

The findings are being reported Jan. 27 in the online version of Nature Immunology and in the February issue of the publication.

Led by Dr. Nicole Suciu-Foca, professor of clinical pathology, the researchers provide evidence for how increasing the amount of ILT3 and ILT4 on dendritic cells could create tolerance to foreign tissues, such as donor tissue or bone marrow. Their results also suggest that somehow decreasing the amount of ILT3 and ILT4 on these cells might allow the body to better fight AIDS and cancer cells.

ILT3 and ILT4 on dendritic cells function as a brake for the immune system, shutting off the immune response and then creating a state of tolerance to antigens, which can be foreign or derived from the body itself, explains Dr. Suciu-Foca. To shut down the immune response, the body presses its “foot” harder on the brake pedal to boost ILT3 and ILT4 activity in the dendritic cells. To enhance the immune response, the body lowers the ILT3 and ILT4 activity.

In the study, the investigators showed how other cells of the immune system, the T-suppressor cells, are responsible for slowing down the activity of the dendritic cells. Dendritic cells present to T cells, including T suppressor cells, the specific antigen against which the immune response had been initiated.

In the study, the researchers showed in cell culture how increasing the activity of ILT3 and ILT4 on dendritic cells could make the immune system tolerant to antigens. They also analyzed the blood of heart transplant recipients and showed that those who did not reject donor hearts had T-suppressor cells that induced the activity of ILT3 and ILT4 in donor dendritic cells. The results show that the heart recipients without rejection had T-suppressor cells that had been primed to suppress a response to foreign hearts.

The findings of the study also have implications for type I diabetes and other autoimmune diseases, Dr. Suciu-Foca says. In autoimmune disease, the immune system attacks normal body tissue rather than being tolerant of it. Enhancing activity of ILT3 and ILT4 in dendritic cells, which present the target antigen in such patients, might help affected patients suppress the immune response against their own tissues.

Dr. Suciu-Foca and her colleagues are now investigating the possible use of ILT3 and ILT4 to treat patients with AIDS, cancer, or transplants.

The research was supported by grants from the National Institutes of Health and the Interuniversity Organ Transplantation Consortium in Rome, Italy.

Contact: Annie Bayne
212-305-3900
as862@columbia.edu



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map