ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Natural Remedies for the Prevention of Dry Eyes

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

What Makes Spanish Marjoram Oil Special?

CoQ10's Potential Capabilities for Your Health

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

8 Chia Seed Recipes

 
Print Page
Email Article

Protein Glitch May Be Early Problem In Inherited Alzheimer's

  [ Not Yet Rated ]   [ Discuss This Article ]
By Press Release by Johns Hopkins Med Institutions • www.ProHealth.com • August 7, 1996


Johns Hopkins scientists have assembled the first clues to the behavior of presenilin, a protein linked to an inherited form of Alzheimer's disease.
In a report published in the July issue of Neuron, they show that presenilin normally cleaves in two and that a disease causing mutation in presenilin can prevent the cleavage. Cleavage is an important change for a protein--it probably has a significant effect on what the protein does. If researchers can find where presenilin cleaves and the enzyme that cleaves it, intervening at this point with drugs or other treatments might be ideal, according to Sangram Sisodia, Ph.D., an associate professor of pathology and neuroscience.

Sisodia and Gopal Thinakaran, Ph.D., David Borchelt, Ph.D., and Michael Lee studied presenilin in cell cultures and in mice that contained copies of the human presenilin gene. Presenilin is a long protein that snakes in and out of the membranes of nerve cells. It is found in an altered form in nearly 60 percent of all "early onset" familial Alzheimer's disease (FAD) cases, cases where symptoms first appear in patients in their late 20s to the their late 50s.

Because presenilin is present only at very low levels, Sisodia notes, it's unlikely to be directly causing the widespread damage to nerve cells seen in FAD, but it may interfere with other proteins that could. Like dominoes falling, a change in presenilin sets off a chain reaction. "Think of it as a cascade," says Sisodia. "We don't know how many steps there are in this cascade, but we have a theory about where the cascade is headed."
According to Sisodia, mutated forms of presenilin may influence the formation of plaques in the brain that are among the earliest signs of Alzheimer's disease.

Hopkins researchers currently are looking at mice in which the gene for presenilin is knocked out so that presenilin's function may be revealed by its absence. Scientists estimate that 15 percent of Alzheimer's patients are FAD victims. A child with one parent with FAD has a 50 percent chance of developing Alzheimer's, a condition characterized by memory loss, dementia, and unusual plaque build-up and nerve cell tangles in the brain.

The study also was presented at the recent International Alzheimer's Disease Conference in Osaka, Japan. It was supported by the National Institutes of Health and the National Cancer Institute, the Adler Foundation, the Alzheimer's Association, and the Develbiss Fund.

Source: Johns Hopkins Medical Institutions Press Release: August 7,1996

Contact: Michael Purdy, mpurdy@welchlink.welch.jhu.edu, 410-955-8725



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Breaking Through the Mental Fog Breaking Through the Mental Fog
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map