ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

 
Print Page
Email Article

Study may help explain sunlight's role in melanoma development, have screening implications

  [ 103 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 24, 2003


CHAPEL HILL -- A strong link exists between lifetime exposure to ultraviolet light, particularly lifetime sunburns, and the development of melanoma - the most lethal form of skin cancer.

Now, for the first time, scientists have identified a specific molecular pathway within cells that becomes mutated by ultraviolet light exposure, thereby speeding up melanoma development.

New findings published in the Feb. 4 issue of Proceedings of the National Academy of Sciences may have implications for screening people at high risk, including those "with a significant history of sunburn and suspicious skin moles," said study co-author, Dr. Norman Sharpless, assistant professor of medicine and genetics at the University of North Carolina at Chapel Hill School of Medicine and a member of UNC's Lineberger Comprehensive Cancer Center.

"Who hasn't been sunburned?" he said. "This work suggests a rational method for risk stratification, for screening questionable skin moles - atypical nevi - for specific molecular lesions."

In the new study, Sharpless and colleagues at Harvard Medical School used mice deficient in an important tumor suppressor protein connected to the "anti-cancer" cell signaling pathway ARF-p53. In addition to this deficiency, these mice were genetically designed to produce another protein, H-Ras, in their pigmented skin cells, or melanocytes.

"Loss of ARF-p53 and activation of Ras are two of three hallmark events detected in human melanomas. The third being loss in another 'anti-cancer' cell signaling pathway, p16INK4a-Rb," said Sharpless.

This mouse model allowed researchers to selectively test the effects of ultraviolet light exposure on the p16INK4a-Rb pathway.

The Rb pathway regulates cell growth. The retinoblastoma protein acts to hold cell proliferation in check. The regulatory capacity of Rb is moderated by CDK6 and the tumor suppressor protein, p16INK4a.

In this work, the authors showed that ultraviolet light exposure accelerated melanoma formation on the treated mice compared with melanomas arising spontaneously in the absence of such exposure. The researchers found targeting of the Rb pathway, either by an increase in CDK6 expression or a loss of p16INK4a, in the melanomas that developed on mice treated with a single exposure of ultraviolet light - essentially, a mouse sunburn. In mice genetically engineered to lack p16INK4a, however, ultraviolet light exposure did not increase melanoma formation.

"These data suggest that it is not so much this gene or that gene, but the pathway that is what UV light targets," Sharpless said.

"This is one of the better mouse models for any human tumor that I'm aware of," he added. "This finding is unique in that it identifies the Rb pathway as a target of UV's mutagenic action."

The next research step is to look at a collection of clinical samples to determine if exclusive lesions in the Rb pathway are linked to melanomas from patients with a detailed history of ultraviolet light exposure.

"Melanoma screening is a good idea, but it needs some molecular help to distinguish the really high-risk patients from those at a lower risk for developing melanoma," Sharpless said. "This would be a way to deal with this very large clinically heterogeneous population of patients at risk."

The Howard Hughes Medical Institute and the National Institutes of Health provided funding for the research.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map