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Abnormalities in Chronic Fatigue Syndrome not due to inactivity

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By Source: Healthwatch • • January 1, 1998

Researchers used quadriceps needle biopsies to examine the muscles of 105 CFS patients. They wanted to find out if abnormalities could be due to lack of activity. Muscle atrophy from inactivity would have resulted in an increased number of a particular type of muscle fiber, called muscle fiber type 2, as well as fiber atrophy. The researchers found that muscle fiber type 1, not type 2, was predominant, and that fiber atrophy was only present in 10% of the patients. This meant that there was no sign of abnormality that could have been due to inactivity. However, they did find that some CFS patients had an abnormal lactate response to exercise, and that these patients had a lower proportion of mitochondria-rich type 1 muscle fibers.

Lane, R.J., et. al. (March 1998). Muscle fiber characteristics and lactate responses to exercise in chronic fatigue syndrome. Journal of Neurology, Neurosurgery and Psychiatry, 64:3, pp. 362–367.

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