ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

AMA journal associates iron deficiency with hearing loss

Why the Mediterranean Diet Is so Successful

 
Print Page
Email Article

MCG Researcher Develops Animal Model For Studying Autoimmune Disease

  [ 5 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 13, 2002




What triggers the immune system to attack the body, as it does in autoimmune diabetes, is the ultimate goal of a Medical College of Georgia researcher who has developed a mouse model to help make that finding possible.

Dr. Pandelakis Koni, immunologist, has developed a conditional knockout mouse in which cellular communication that triggers the immune response to an invader can be selectively stopped. His mouse is featured in a special February issue of Genesis: The Journal of Genetics and Development, which contains 43 papers documenting the development of new animal models available for use by researchers across the world.

Dr. Koni is studying a type of surveillance cell called dendritic cells that stand on patrol throughout the body looking for invaders. "If you have an infection or some foreign agent in your body, dendritic cells detect it and are very good at picking it up and delivering it to the right place to switch on your immune system," he said. "They literally eat up bacteria, put them inside their vesicles, where a lot of acids and digestive enzymes chop them up. Eventually, a small piece of protein from the bacteria makes its way to the surface of the dendritic cell," he explained.

This is where Dr. Koni interrupts the process. Dendritic cells have on their surface major histocompatibility complex molecules, or MHC molecules, that take up these pieces of protein and literally hold them up for another immune system cell called T cells. "The T cell comes along with its own surface protein which is designed so it can survey that surface." Those T cell receptors lock onto the MHC molecule on the dendritic cell. The T cell then switches on, begins to proliferate and determines what other immune components it needs to summon

"The conditional knockout we made enables us to eliminate the MHC molecule from different types of dendritic cells," Dr. Koni said. The four general types of dendritic cells are Langerhans' cells primarily found in the skin, myeloid dendritic cells found throughout most solid body tissue, plasma cytoid dendritic cells thought to be involved in clearing viral infections and lymphoid tissue dendritic cells found in the lymph nodes and spleen.

He's most interested in the plasma cytoid and lymphoid tissue types not only because of their role in natural immunity, but because they are thought to have an important role in preventing autoimmune disease.

"We think they might also be involved in controlling your immune system so you don't attack yourself," Dr. Koni said. "We want to be able to get rid of the MHC molecule to see not only what happens to your ability to fight viral infections or bacterial infections, but to see what happens to your ability to protect yourself from autoimmunity."

He's genetically engineered a mouse by inserting DNA recognition signals called loxP on either side of the gene that makes the MHC molecule involved in signaling T-cells. This mouse can be bred with others called CRE mice; CRE is a bacterial enzyme whose natural function is to recognize loxP, remove it and whatever is in between. So the offspring of these two mice will have the MHC molecule selectively removed from the varying types of dendritic cells. Right now Dr. Koni is working on developing CRE mice that remove the molecules from the plasma cytoid and lymphoid tissue dendritic cells. "I'm relying on the mice that we make to study autoimmune disease," he said.

Multiple sclerosis occurs when the immune system attacks the insulation of nerves called myelin, ultimately resulting in loss of motor and sensory function. "Some people say it's a virus that triggers (the attack). But whatever triggers it, you start to attack your cells with immune-based weapons that rely on the whole system being switched on. In that situation, we would like to be able to switch it off again," he said.

In type 1 diabetes, pancreatic islet cells undergo similar attack, resulting in insulin deprivation and a myriad of related problems. "We don't know what kicks (the immune system) off or how you can prevent it from continuing. You need to know how to do that, how you can stop the autoimmune disease from continuing," Dr. Koni said.

He's interested as well is understanding basic immunology. "How do dendritic cells talk to T cells and how can that whole network of regulation and keeping everything under control fail? What are the molecules involved in how normal works and how it goes wrong when you have autoimmune diabetes?"

Dr. Koni's research is funded by the National Institutes of Health.


Source: Medical College of Georgia web site (www.mcg.edu)



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Break Free From Fibromyalgia Break Free From Fibromyalgia
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map