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Alzheimers disease is not associated with hypertension genetic risk factors

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By Town T, Paris D, Parker TA, Kundtz A, Tan J, Duara R, Gold M, Crawford F, Mullan M. The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA. • www.ProHealth.com • March 2, 2000


SUMMARY: This study examines the evidence that Alzheimer's and hypertension may be caused by the same genetic factors. Researchers conducted experiments on genes affected by each disease. They compared the results and did not find a genetic link between Alzheimer's and hypertension. They reported that the diseases do not share the same genetic cause.

Growing evidence suggests that hypertension and Alzheimers disease (AD) may share a common etiology.

To evaluate the contribution to AD of genetic factors associated with hypertension, we genotyped clinic and community-based AD cases and controls for polymorphisms within the pancreatic PLA(2) gene and the G protein beta3 subunit gene, both of which are located on chromosome 12.

Our results do not support an independent association between either of these genes and AD. We further assessed the possibility that either of these genes may interact with the apolipoprotein E gene, a known risk factor for hypertension and AD, on predicting AD.

We were unable to find statistical interaction between either the pancreatic PLA(2) or Gbeta3 genes and the apolipoprotein E gene on risk for AD.

These results do not support a shared genetic etiology between hypertension and AD. Possibly, a clinical association between these diseases could be due to pathophysiologic interactions.




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