ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

Why the Mediterranean Diet Is so Successful

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

More evidence for calorie restriction’s longevity effect

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

 
Print Page
Email Article

Purdue Genetic Discovery May Aid Plants and Human Medicine

  [ 133 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 26, 2003


WEST LAFAYETTE, Ind. - Findings that two mutated genes alter plant growth and development could result in improved plants and enhanced cancer treatments, according to Purdue University researchers.

In a paper published in Thursday's (6/26) issue of Nature, the scientists report that these abnormal, or mutant plants are able to reorient themselves in response to light and gravity more rapidly than normal, or "wild type," plants. Apparently plants behave differently in accordance with how a growth hormone moves through them. Because the two genes affecting transport of the hormone are related to human genes that impact the effectiveness of chemotherapy drugs, controlling these genes may allow physicians to better determine the dosage of cancer drugs.

"We now know that if we can modify these genes, we can control the growth of the plant in very specific regions," said Angus Murphy, assistant professor of horticulture and senior author of the paper. "This means we might be able to change the shape of upper portions of a plant or develop a more robust root system."

These genes are related to multidrug resistance (MDR) genes in humans. MDR genes transport anticancer drugs out of cells, rendering the treatment less effective. The genes are designated with capital letters, while the mutated, or altered, genes are designated with small letters (in this case, mdr). Murphy's research group found and studied the altered genes in the commonly used experimental plant, Arabidopsis(pronounced: Ah-rob-ah-dop-sis).

The Arabidopsis mdr mutations disrupt the accumulation of a protein, PIN1, at the base of cells in the stems of plant embryos, Murphy said. Because PIN1 is an essential part of the system that transports the growth hormone auxin, dislocation of the protein impairs flow of the hormone through the plant. This alters how the plants develop and respond to factors such as light and gravity.

Relocation of PIN1 and selective disruption of auxin transport makes plants bushier and affects fruit production. Transport of auxin to roots is actually enhanced in some mdr mutants, so the same gene modifications may alter root structures to make plants more adaptable to different soil types.

In addition, discovery that MDR-like genes play an integral role in transport of auxin could impact human cancer chemotherapy treatments, Murphy said. Researchers already know that MDRs move the drugs out of cancer cells, but they don't know what other transport functions they perform or exactly how they work.

"We're assuming that they work together with other transport proteins to move toxic compounds out of cells, but we don't really know," Murphy said. "The idea that they could be affecting where those transport proteins go in human cells has tremendous implication for studies in humans as well as plants."

One way to find out more about transport proteins is to find out how a gene affects a plant's development.

"We learned how these genes function by knocking out the gene," Murphy said. "This is the genetic equivalent of taking a car from the assembly line and just pulling out a particular part. When the car is finished without the part, you see what works and what doesn't.

"In this case, we have removed two parts with similar functions to find out more about what they do."

Murphy said the research team would like to alter plant growth by changing the gene slightly rather than turning it off altogether. They know that one MDR mutation in another plant species results in plants that are shorter and stockier with a bigger root system than in the wild type. These mutants are more resistant to wind and may be more robust in difficult environments where the soil is poor and the climate is arid.

"Timing is also important," he said "If we can turn these genes on and off at the right times, we may be able to enhance a valuable trait.

"For instance, right now you have to mechanically pinch off chrysanthemums so they will spread, or apply a growth regulator to produce useful ornamental plants from cuttings. If, instead, we could insert a program into the plant to activate or inactivate auxin transport at a particular time and in a particular part of the plant then the plant would automatically become bushier or produce more flowers."

Further research on auxin transport will investigate whether other MDR family members influence PIN1 distribution and also what specific relationships exist between members of the MDR and PIN families of transport proteins.

The other authors of this study were Bosl Noh, now a senior research scientist at Kumho Life and Environmental Science Laboratories in Korea; Anindita Bandyopadhyay, a Purdue horticulture doctoral student; Wendy Peer, Purdue horticulture research scientist; and Edgar Spalding, University of Wisconsin associate professor of botany.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map