ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Can Magnesium Relieve Your Tinnitus?

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Restoring NAD+ could reduce DNA damage accumulation

 
Print Page
Email Article

Rare Versions of Immune System Genes Stave Off HIV Infection

  [ 15 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 8, 2003


Researchers have new answers as to why some HIV-infected individuals don't progress to full-blown AIDS as rapidly as other HIV-positive people.

Northwestern University scientist Steven M. Wolinsky, M.D., and colleagues found that individuals with certain rare variations, or alleles, of two immune system genes -- human leukocyte antigens A and B (HLA-A and HLA-B) -- are better equipped to stave off HIV than people with more common sets of HLA alleles.

This finding indicates that HIV has evolved to attack the most common immune system genes and that there may be differences in how people respond to infection based on their HLA proteins. Importantly, the research, which was published in the July issue of Nature Medicine, showed that HIV influences human immune response just as humans put evolutionary pressure on the virus.

"We're pushing on the microbe and it's pushing back on us," Wolinsky said.

The group's study, which was conducted in 996 HIV-infected men in Chicago component of the Multicenter AIDS Cohort Study (MACS), also has major therapeutic implications for determining the patients who require more aggressive treatment and for developing AIDS vaccines, Wolinsky said.

Wolinsky is the Samuel J. Sackett Professor and chief of infectious disease at the Feinberg School of Medicine and at Northwestern Memorial Hospital. He also is director of the Great Lakes Regional Center for AIDS Research.

HLA molecules help trigger activity of infection-fighting T cells. During the immune response, HLA proteins bind bits of an invading microbe's proteins in an infected cell, which are then presented on the infected cell's surface to killer T cells. The killer T cells, also known as cytotoxic T cells, destroy the infected cell and thereby prevent spread of infection.

Importantly, the study demonstrated the first clinical application of a new statistical method, called minimum description length (MDL), that enabled the researchers to analyze the hundreds of HLA-A and HLA-B alleles found in the Chicago HIV study population and classify patients into disease progression groups based on their ability to bind specific microbial proteins. The investigators were then able to associate nine different HLA "supertypes" with disease outcome.

They found that men with the most frequent HLA supertypes had the highest viral loads – less HIV in their blood -- while the men with the least frequent supertypes had the lowest. One of study's more significant findings was that black men had lower viral loads than white men.

Findings from the study are especially pertinent to the development of AIDS vaccines. Since it appears that HIV has evolved to assail the most frequent alleles in the population, any vaccine designed to help killer T cells control HIV infection – which is based on the HLA – might not provide protection, Wolinsky said.

Further, because immune system alleles – and, thus disease progression rates -- vary with different populations and geographical areas, it is therefore possible that AIDS vaccines will have to be tailored to specific locations or even for individual patients. Wolinsky's co-researcher were Elizabeth Trachtenberg, Children's Hospital Oakland Research Institute Bette Korber, Los Alamos National Laboratory and Thomas Kepler, Duke University, among others.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map