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Defects in Mitochondrial Function Linked to Alzheimer’s Disease

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By AlzheimerSupport Staff • www.ProHealth.com • July 4, 2000


Medical researchers at the University of Virginia Health System have succeeded in directly linking the brain cell damage and death that are hallmarks of Alzheimer's disease (AD) to abnormalities in mitochondrial genes. The research is published in the July issue of Annals of Neurology.

Mitochondria, which are descended from primitive bacteria, are the "powerhouses" of our cells that provide usable energy. Their genes are small pieces of circular DNA that are passed from mother to children. Abnormalities in mitochondrial genes have been associated with rare brain diseases in children and adults. This study shows that defective mitochondrial genes may cause Alzheimer's, the most common degenerative brain disease in adults.

"For us, this is a major finding," said Dr. James P. Bennett Jr., a neurologist at U.Va. and principal investigator of the study. "We show that a likely source of increased secretion and deposition of beta amyloid in the brains of AD patients derives from the defects in mitochondrial function induced by defective AD mitochondrial genes."

Using cell systems or cybrids made from platelet mitochondria of five sporadic AD subjects and five age-matched, neurologically normal controls, the U.Va. researchers examined amyloid metabolism and mitochondrial function in the disease.

"Prior work on amyloid secretion centered on the rare inherited forms that account for only about 10 percent of the cases," Bennett said. "We built our cybrids using mitochondria from people with sporadic or non-familial AD, which accounts for more than 90 percent of AD cases."

They found that the defective mitochondrial genes in AD cybrid cells caused increased damage from oxygen free radicals ("oxidative stress"), because of the inefficient processing of oxygen into water.

This led to the activation of cell death pathways, which resulted in the over secretion of beta amyloid peptides and the forming of plaque-like areas in the cells. Blocking the activation of cell death pathways eliminated the abnormal beta amyloid secretion.

AD, which effects an estimated three to five million Americans, is characterized by two changes in the brain tissue: senile or neuritic plaques, chemical deposits consisting of degenerating nerve cells combined with a form of protein called beta amyloid, and neurofibrillary tangles, malformations within nerve cells.

The plaques found in the brains of people with Alzheimer's appear to be made, in part, from protein molecules -- amyloid precursor protein or APP -- that normally are essential components of the brain. Plaques are made when an enzyme snips APP apart at specific places and then leaves the fragments or beta amyloid in brain tissue, where they come together in abnormal deposits.

The latest findings by Bennett and his colleagues reinforce their view that beta amyloid plaque formation is an effect, or marker, of an underlying cause.

"As a result of this study we are now much closer to understanding how AD develops in the 90 percent of patients who have the so-called sporadic form that tends to appear in those without a strong family history of the disease," Bennett said. "Our findings in these AD patients firmly link together defective mitochondrial genes and abnormal beta amyloid metabolism, which is the biochemical hallmark of the disease.

"Finding out what causes AD's damage to brain cells provides possible avenues for new research, and hopefully the development of drugs that will reduce the abnormal oxidative stress in the mitochondria. If we can lessen cell death in AD brains, we should be able to slow the progression of the debilitating symptoms of this tragic disease."

Source: University of Virginia Health Center



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