ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Designer Chemical Offers Alzheimer's Treatment Hope

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 17, 2001




Researchers at the University of Illinois at Chicago have designed and synthesized highly potent inhibitor compounds that could lead to an effective treatment for Alzheimer’s disease. The work was reported in the American Chemical Society’s Journal of Medicinal Chemistry.

Arukn Ghosh, professor of chemistry at UIC, and Jordan Tang head of the Protein Studies department at the Oklahoma Medical Research Foundation in Oklahoma City, designed an inhibitor that blocks the action of one of two protein-cutting enzymes, called proteases, thought to be responsible for Alzheimer’s disease.

The enzyme, called memapsin 2, severs a longer protein in the brain called amyloid precursor protein, or APP, to produce beta-amyloid, which accumulates in the brain and forms plaques that lead to the development of Alzheimer’s disease. “This enzyme is probably the most exciting target for an Alzheimer’s drug,” said Ghosh.

Tang discovered the precise location where memapsin 2 cuts APP. Subsequently, Tang and Ghosh demonstrated that a model inhibitor compound attracts memapsin 2 and keeps it from cutting APP. It is a promising way to halt accumulation of beta-amyloid in the brain. The inhibitor was reported in the Journal of the American Chemical Society last year and was shown to be effective in test tube experiments.

The research team knew that while useful as a model, the inhibitor would not be effective in drug therapy. “That was a preliminary inhibitor,” said Ghosh. “It’s a big one, containing eight peptides - a size that is inconceivable to be a drug candidate.”

Ghosh and his team set out to reduce the molecule’s size in an effort to increase its potential as a drug candidate.

“Peptide-like compounds never make useful drugs because they’re metabolically unstable, they’re insoluble and, perhaps the biggest problem in Alzheimer’s patients, they’re hard to deliver in the human brain,” Ghosh said. The molecule has to be small enough to cross what’s called the blood-brain barrier. “Peptide-like molecules are not very good at penetrating this barrier. Our ultimate goal is to deliver a totally non-peptide inhibitor,” he said.

The current study describes a new generation of inhibitors designed and tested in the laboratory. These new inhibitors are still potent yet substantially smaller, comparable in size to HIV protease inhibitor drugs now being prescribed.

“Designing a smaller, more potent inhibitor is an important step in the development of an effective treatment for Alzheimer’s patients,” said Tang.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map